Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids
Abstract
:1. Introduction
1.1. Neonatal Abstinence Syndrome (NAS)
1.2. Epidemiology and Economic Issues
2. Treatment of NAS
2.1. Nonpharmacological Interventions
2.2. Pharmacological Interventions
2.3. Neurodevelopmental Issues with Opioid Treatment
2.4. A Case in Favor of Non-Opioid Treatment in NAS
2.5. Snapshot of Dopaminergic Mechanisms in Addiction
2.6. Evidence-Based Prodopaminergic Regulation (KB220)
2.7. Common Neurochemical Mechanisms Related to Alcohol and Opiate/Opioid-Induced Withdrawal Symptomatology
2.8. Genetic Addiction Risk Severity (GARS): Promoting the Early Identification of Polymorphic Risk Alleles in RDS
3. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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GARS Listed Nutrient | Neuroadaptagen Target |
---|---|
D-Phenylalanine | Opioid peptides |
L-Phenylalanine | Dopamine |
L-tryptophan | Serotonin |
L-Tyrosine | Dopamine |
L-Glutamine (low dose) | GABA |
Chromium | Serotonin |
Rhodiola Rosea | COMT/MOA |
Passionflower (low dose) | Benzodiazepine = GABA complex |
Pyridoxine | Enzyme Catalyst |
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Ceccanti, M.; Blum, K.; Bowirrat, A.; Dennen, C.A.; Braverman, E.R.; Baron, D.; Mclaughlin, T.; Giordano, J.; Gupta, A.; Downs, B.W.; et al. Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids. J. Pers. Med. 2022, 12, 2015. https://0-doi-org.brum.beds.ac.uk/10.3390/jpm12122015
Ceccanti M, Blum K, Bowirrat A, Dennen CA, Braverman ER, Baron D, Mclaughlin T, Giordano J, Gupta A, Downs BW, et al. Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids. Journal of Personalized Medicine. 2022; 12(12):2015. https://0-doi-org.brum.beds.ac.uk/10.3390/jpm12122015
Chicago/Turabian StyleCeccanti, Mauro, Kenneth Blum, Abdalla Bowirrat, Catherine A. Dennen, Eric R. Braverman, David Baron, Thomas Mclaughlin, John Giordano, Ashim Gupta, Bernard W. Downs, and et al. 2022. "Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids" Journal of Personalized Medicine 12, no. 12: 2015. https://0-doi-org.brum.beds.ac.uk/10.3390/jpm12122015