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Microorganisms
Volume 8
Issue 8
10.3390/microorganisms8081222
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Review
Peer-Review Record

Targeting Biofilms Therapy: Current Research Strategies and Development Hurdles

Microorganisms 2020, 8(8), 1222; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms8081222
by Yu Jiang, Mengxin Geng and Liping Bai *
Reviewer 1: Anonymous
Microorganisms 2020, 8(8), 1222; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms8081222
Submission received: 7 July 2020 / Revised: 31 July 2020 / Accepted: 7 August 2020 / Published: 11 August 2020
(This article belongs to the Special Issue Microbial Films-the Interplay of Physics and Biology)

Round 1

Reviewer 1 Report

The scientific data is compiled well but the presentation could be a lot better. The flow of the text and the choice of words is not very good and the manuscript will be hugely benefitted by having it edited by a professional language editor.

 

Author Response

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Author Response File: Author Response.docx

Reviewer 2 Report

  1. Line 10 and whenever appropriate: Biofilm is not a virulence factor. Many publications use this incorrect statement. It is a growth state of microorganisms. Please revise it. Production of virulence factors varies in planktonic versus biofilm bacteria.
  2. Line 20: Avoid unnecessary upper-case letter and delete I from QSI.
  3. 1: The text in the diagram is not clear. The quality should be improved. Additionally, it will be better if cartoon is drawn with bacterial cells.
  4. Lines 134 and 135: Please specify what type of coli?
  5. Line 149: Delete ing from targeting
  6. Many places (e.g., lines 175-178) the genus and species are not italicized.
  7. Table 2: any specific example of cysteine proteases secreted by mesenchymal stromal cells?
  8. Line 452 (Targeting dormant cells in biofilms): DNA cross-linking drugs like cisplatin (Biotechnol Bioeng 2016,113:1984-1992) and mitomycin C (Environ Microbiol 2015, 17:4406-4414) have been proved to eradicate biofilm/dormant cells. So, it is important to include a brief section on this citing these papers.

Author Response

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Author Response File: Author Response.docx

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