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Case Report

Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients

1
Institute of Virology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Fürst-Pückler Straße 56, 50935 Cologne, Germany
2
Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany
3
Department of General, Visceral, Cancer and Transplant Surgery, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany
4
CECAD, Faculty of Medicine, University Hospital Cologne, University of Cologne, Joseph-Stelzmann Straße 26, 50931 Cologne, Germany
5
Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Academic Editor: Stefano Aquaro
Received: 15 July 2021 / Revised: 30 July 2021 / Accepted: 2 August 2021 / Published: 4 August 2021
(This article belongs to the Special Issue Molecular and Therapeutic Aspects of Viral Infections)
The treatment options for cytomegalovirus (CMV) infections in immunosuppressed patients are limited, mainly consisting of (val-)ganciclovir (VGC/GCV) as the first-line treatment. We report on three transplant recipients, one stem cell transplant (allo-HSCT) patient and two kidney transplant (KTx) recipients, with prolonged CMV viremia treated with a combined therapy based on letermovir (LMV), CMV-specific intravenous immunoglobulins (IVIg), and VGC/GCV, which led to the sustained control of CMV viremia in all patients. View Full-Text
Keywords: CMV; ELISPOT; drug resistance; kidney; bone marrow; transplantation; immunosuppression; opportunistic infection; combination; cellular response CMV; ELISPOT; drug resistance; kidney; bone marrow; transplantation; immunosuppression; opportunistic infection; combination; cellular response
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MDPI and ACS Style

Di Cristanziano, V.; Affeldt, P.; Trappe, M.; Wirtz, M.; Heger, E.; Knops, E.; Kaiser, R.; Stippel, D.; Müller, R.-U.; Holtick, U.; Scheid, C.; Kann, M.; Kurschat, C.E.; Grundmann, F. Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients. Microorganisms 2021, 9, 1666. https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms9081666

AMA Style

Di Cristanziano V, Affeldt P, Trappe M, Wirtz M, Heger E, Knops E, Kaiser R, Stippel D, Müller R-U, Holtick U, Scheid C, Kann M, Kurschat CE, Grundmann F. Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients. Microorganisms. 2021; 9(8):1666. https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms9081666

Chicago/Turabian Style

Di Cristanziano, Veronica, Patrick Affeldt, Moritz Trappe, Maike Wirtz, Eva Heger, Elena Knops, Rolf Kaiser, Dirk Stippel, Roman-Ulrich Müller, Udo Holtick, Christoph Scheid, Martin Kann, Christine E. Kurschat, and Franziska Grundmann. 2021. "Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients" Microorganisms 9, no. 8: 1666. https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms9081666

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