Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Chemicals
2.2. Animals
2.3. Experimental Design
2.4. HPLC and Chromatographic Conditions
2.5. Pharmacokinetic Analysis
2.6. Determination of MICs
2.7. PK/PD Integration
2.8. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Parameters | 10 mg/kg | 20 mg/kg | 40 mg/kg |
---|---|---|---|
t1/2ʎz (h) | 33.82 | 37.31 | 40.68 |
AUC0–24 (h*µg/mL) | 82.02 | 145.07 | 433.27 |
AUC0–last (h*µg/mL) | 236.92 | 469.49 | 1485.59 |
AUC0–∞ (h*µg/mL) | 242.02 | 475.50 | 1513.09 |
AUCextrap (%) | 2.11 | 1.26 | 1.82 |
MRT0–∞ (h) | 54.03 | 59.47 | 63.23 |
CL/F (mL/h/kg) | 41.32 | 42.06 | 25.44 |
Vdarea/F (L/kg) | 2.02 | 2.26 | 1.55 |
Cmax (µg/mL) | 4.63 | 7.86 | 24.09 |
Tmax (h) | 5.04 | 6.35 | 7.13 |
Distribution (Numbers of Isolates) of Enrofloxacin MIC (μg/mL) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Bacterial Species | N | 0.031 | 0.063 | 0.125 | 0.25 | 0.50 | 1 | 2 | 4 | 8 |
A. hydrophila | 13 | - | 1 | 1 | 7 | 2 | 1 | - | 1 | - |
A. sobria | 13 | - | 2 | 3 | 1 | 4 | 2 | 1 | - | - |
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Uney, K.; Terzi, E.; Durna Corum, D.; Ozdemir, R.C.; Bilen, S.; Corum, O. Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta). Animals 2021, 11, 3086. https://0-doi-org.brum.beds.ac.uk/10.3390/ani11113086
Uney K, Terzi E, Durna Corum D, Ozdemir RC, Bilen S, Corum O. Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta). Animals. 2021; 11(11):3086. https://0-doi-org.brum.beds.ac.uk/10.3390/ani11113086
Chicago/Turabian StyleUney, Kamil, Ertugrul Terzi, Duygu Durna Corum, Rahmi Can Ozdemir, Soner Bilen, and Orhan Corum. 2021. "Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)" Animals 11, no. 11: 3086. https://0-doi-org.brum.beds.ac.uk/10.3390/ani11113086