Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology
, Martijn F. Hoes, Dirk J. van Veldhuisen, Peter van der Meer and Niels Grote Beverborg *
Round 1
Reviewer 1 Report
In this work, the authors extensively reviewed the mechanism, pathophysiology, and clinical implications of iron deficiency in HF. The authors should be congratulated for this impressive, comprehensive, and updated work.
Just minor comments.
- There are minor typo errors (for instance, line 48).
- I would expand the data (pro/cons) about the adequacy of ESC ID definition in HF. As commented by the authors this definition is somewhat arbitrary.
- I would summarize the most important and current "gaps in the knowledge" in a new figure or table.
- The authors should also mention new lines of research
Author Response
Please see the attachment.
Author Response File: 
Author Response.docx
Reviewer 2 Report
The authors have conducted an extensive and comprehensive review of iron deficiency and its impact on heart failure. It can also be appreciated that the authors correlate both the basic science and clinical presentation of ID as it affects HF. They also take the review a step further and highlight how ID in other organs affects HF patients. The authors also cite major trials that have addressed or are addressing the lack of data on this topic. I commend the authors on their excellent manuscript.
Author Response
Thank you very much for your kind words. We really appreciate you taking the time out to review our manuscript.
