Potential Biomarkers in Experimental Animal Models for Traumatic Brain Injury
Abstract
:1. Introduction
2. Physiology of TBI
2.1. Primary Injury
2.2. Secondary Injury
2.3. Types of TBI
3. Animal Models of TBI
3.1. Animals
3.1.1. Rodents
3.1.2. Non-Rodents
3.2. Experimental Animal Models
3.2.1. Closed-Head Injury Models
Weight-Drop Model
Piston-Driven Model
3.2.2. Open-Head Injury Models
Fluid Percussion Injury Models
Controlled Cortical Impact (CCI) Model
Blast Injury Model
3.3. Unconventional TBI Models
4. Biomarkers of TBI
4.1. Behavioral Biomarkers
4.2. Biochemical Biomarkers
4.3. MicroRNAs
4.4. Neuroimaging Techniques
5. Challenges and Strategies Involved in Clinical Translation
6. TBI in HIV Infection and Drug Abuse
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Deshetty, U.M.; Periyasamy, P. Potential Biomarkers in Experimental Animal Models for Traumatic Brain Injury. J. Clin. Med. 2023, 12, 3923. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm12123923
Deshetty UM, Periyasamy P. Potential Biomarkers in Experimental Animal Models for Traumatic Brain Injury. Journal of Clinical Medicine. 2023; 12(12):3923. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm12123923
Chicago/Turabian StyleDeshetty, Uma Maheswari, and Palsamy Periyasamy. 2023. "Potential Biomarkers in Experimental Animal Models for Traumatic Brain Injury" Journal of Clinical Medicine 12, no. 12: 3923. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm12123923