Does Resveratrol Play a Role in Decreasing the Inflammation Associated with Contrast Induced Nephropathy in Rat Model?
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Experimental Design
2.3. Renal Function and Cytokine Analysis
2.4. Histopathology and Immunochemistry
2.5. Western Blot
2.6. Enzyme-Linked Immunosorbent Assay for Plasma Neutrophil Gelatinase-Associated Lipocalin
2.7. Data Analysis
3. Results
3.1. Resveratrol Attenuated Renal Injury and Protected Renal Function after the Induction of Contrast Nephropathy
3.2. Resveratrol Preserved the Renal Architecture after the Induction of Contrast Nephropathy
3.3. Resveratrol Attenuated Renal Injury Scores after Contrast Nephropathy Had Been Induced
3.4. Effects of Resveratrol on Renal Tubular Apoptosis after Contrast Nephropathy Had Been Induced
3.5. Resveratrol Pretreatment Ameliorated Kidney Inflammation by Blocking NLRP3 Inflammasome Activation after Contrast Nephropathy Had Been Induced
3.6. Resveratrol Pretreatment Attenuated the Expression of Proinflammatory Cytokines in the Kidney after Contrast Nephropathy Had Been Induced
4. Discussion
5. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Chen, Y.-H.; Fu, Y.-C.; Wu, M.-J. Does Resveratrol Play a Role in Decreasing the Inflammation Associated with Contrast Induced Nephropathy in Rat Model? J. Clin. Med. 2019, 8, 147. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm8020147
Chen Y-H, Fu Y-C, Wu M-J. Does Resveratrol Play a Role in Decreasing the Inflammation Associated with Contrast Induced Nephropathy in Rat Model? Journal of Clinical Medicine. 2019; 8(2):147. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm8020147
Chicago/Turabian StyleChen, Yi-Hsin, Yun-Ching Fu, and Ming-Ju Wu. 2019. "Does Resveratrol Play a Role in Decreasing the Inflammation Associated with Contrast Induced Nephropathy in Rat Model?" Journal of Clinical Medicine 8, no. 2: 147. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm8020147