Oxidative Stress and Inflammation in Renal and Cardiovascular Complications of Diabetes

Round 1

Reviewer 1 Report

1. Please summarize part of the information also in a table with the most important information on this topic.

Author Response

As suggested, the important information particularly, the current and potential therapies for DKD and CVD are summarised in a table 1 and is included in the new version of manuscript.

Reviewer 2 Report

This review on the role of oxidative stress and inflammation in renal and cardiovascular complications found in the pathology of diabetes is of good quality.

On the other hand, the authors often talk in different paragraphs about the role of IL-1, TNFα, NF-κB. All these markers are also involved in inflammation with regard to their induction of the cyclooxygenase-2 pathway and its involvement in the metabolism of arachidonic acid. It is essential to add a paragraph on the relationship between increased prostanoid synthesis and renal and cardiovascular complications in the pathology of diabetes, just as the authors have done several paragraphs on the anti-inflammatory role of lipoxins.

Author Response

As suggested, a paragraph on prostanoids and its relevance in DKD (line 127-134) and CVD (line 345-353) is included and is highlighted in yellow in new version of manuscript.

Reviewer 3 Report

Dear Authors, 

The article is very interesting and very well done.Congratulation.The manuscript followed the author's guidelines, the information is well processed, and also the reference list.

Author Response

As suggested, a paragraph on GLP-1 receptor agonist (liraglutide) (line 489-493) and a reference suggested by reviewer is included in the manuscript, see reference number 115.

Round 2

Reviewer 2 Report

This review is now acceptable for publication in Biology.