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Review

Potential Effects of Melatonin and Micronutrients on Mitochondrial Dysfunction during a Cytokine Storm Typical of Oxidative/Inflammatory Diseases

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Instituto de Investigaciones en Ciencias Químicas, Facultad de Ciencias Químicas y Tecnológicas, Universidad Católica de Cuyo, San Juan, Argentina
2
Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
3
Departamento de Fisiología, Facultad de Ciencias Médicas, Universidad Maimónides, Buenos Aires, Argentina
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Department of Cell Systems and Anatomy, UT Health San Antonio Long School of Medicine, San Antonio, TX 78229, USA
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Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina
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Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Mendoza, Argentina
*
Author to whom correspondence should be addressed.
Academic Editor: Alessandra Stacchiotti
Received: 16 March 2021 / Revised: 9 April 2021 / Accepted: 11 April 2021 / Published: 14 April 2021
(This article belongs to the Special Issue Novel Melatonin Based Therapies)
Exaggerated oxidative stress and hyper-inflammation are essential features of oxidative/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may prevent or attenuate mitochondrial damage and may preserve an optimal state of health by managing the general oxidative and inflammatory status. This review aims to describe the crucial role of mitochondria in the development and progression of multiple diseases as well as the close relationship among mitochondrial dysfunction, oxidative stress, and cytokine storm. Likewise, it attempts to summarize the main findings related to the powerful effects of melatonin and some micronutrients (vitamins and minerals), which may be useful (alone or in combination) as therapeutic agents in the treatment of several examples of oxidative/inflammatory pathologies, including sepsis, as well as cardiovascular, renal, neurodegenerative, and metabolic disorders. View Full-Text
Keywords: mitochondrial dysfunction; cytokine storm; melatonin; micronutrients; vitamins; minerals; oxidative-inflammatory disorders; COVID-19 mitochondrial dysfunction; cytokine storm; melatonin; micronutrients; vitamins; minerals; oxidative-inflammatory disorders; COVID-19
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MDPI and ACS Style

Martín Giménez, V.M.; de las Heras, N.; Ferder, L.; Lahera, V.; Reiter, R.J.; Manucha, W. Potential Effects of Melatonin and Micronutrients on Mitochondrial Dysfunction during a Cytokine Storm Typical of Oxidative/Inflammatory Diseases. Diseases 2021, 9, 30. https://0-doi-org.brum.beds.ac.uk/10.3390/diseases9020030

AMA Style

Martín Giménez VM, de las Heras N, Ferder L, Lahera V, Reiter RJ, Manucha W. Potential Effects of Melatonin and Micronutrients on Mitochondrial Dysfunction during a Cytokine Storm Typical of Oxidative/Inflammatory Diseases. Diseases. 2021; 9(2):30. https://0-doi-org.brum.beds.ac.uk/10.3390/diseases9020030

Chicago/Turabian Style

Martín Giménez, Virna M., Natalia de las Heras, León Ferder, Vicente Lahera, Russel J. Reiter, and Walter Manucha. 2021. "Potential Effects of Melatonin and Micronutrients on Mitochondrial Dysfunction during a Cytokine Storm Typical of Oxidative/Inflammatory Diseases" Diseases 9, no. 2: 30. https://0-doi-org.brum.beds.ac.uk/10.3390/diseases9020030

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