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Volume 82
Issue 4
10.3797/scipharm.1405-04
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities

by
Cigdem YORUR-GORECI
1,*,
Nilay ALTAS-KIYMAZ
2,
Aysegul PEKSEL
2,
Belkis BILGIN-ERAN
1 and
Mustafa SONMEZ
1
1
Department of Organic Chemistry, Faculty of Arts and Sciences, Yildiz Technical University, 34210, Esenler/Istanbul, Turkey
2
Department of Biochemistry, Faculty of Arts and Sciences, Yildiz Technical University, 34210, Esenler/Istanbul, Turkey
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2014, 82(4), 735-748; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1405-04
Submission received: 8 May 2014 / Accepted: 1 July 2014 / Published: 1 July 2014
Versions Notes

Abstract

A series of new p-nitrophenylhydrazone derivatives 3a–f were synthesized, characterized, and investigated for their antioxidant activities. These com-pounds have been synthesized by refluxing (p-nitrophenyl)hydrazine with 4-sub-stituted salicylaldehydes. The structures of the compounds were established by IR, 1H- and 13C-NMR, and MS data. The antioxidant activities (free radical-scavenging activity, reducing power, metal chelating activity, and total anti-oxidant activity) of the hydrazone compounds were evaluated. All of the compounds exhibited significant activities, while compound 3a, with the shortest chain, showed the highest antioxidant activity in all of the tests.
Keywords: Antioxidant activity; Metal chelating activity; Phenylhydrazones; Radical scavenging activity; Reducing power; Total antioxidant activity Antioxidant activity; Metal chelating activity; Phenylhydrazones; Radical scavenging activity; Reducing power; Total antioxidant activity

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MDPI and ACS Style

YORUR-GORECI, C.; ALTAS-KIYMAZ, N.; PEKSEL, A.; BILGIN-ERAN, B.; SONMEZ, M. New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities. Sci. Pharm. 2014, 82, 735-748. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1405-04

AMA Style

YORUR-GORECI C, ALTAS-KIYMAZ N, PEKSEL A, BILGIN-ERAN B, SONMEZ M. New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities. Scientia Pharmaceutica. 2014; 82(4):735-748. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1405-04

Chicago/Turabian Style

YORUR-GORECI, Cigdem, Nilay ALTAS-KIYMAZ, Aysegul PEKSEL, Belkis BILGIN-ERAN, and Mustafa SONMEZ. 2014. "New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities" Scientia Pharmaceutica 82, no. 4: 735-748. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.1405-04

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