The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Blood and CSF Samples
2.3. Analysis of Antioxidants and Oxidative Stress Markers
2.4. Evaluation of Clinical Data and Imaging
2.5. Statistical Analysis
2.6. Ethics Declarations
3. Results
3.1. Baseline Demographics and Follow-Up
3.2. Superoxide Dismutase (SOD) in Plasma and CSF
3.3. Glutathione Peroxidase (GSH-Px) in Plasma and CSF
3.4. Glutathione-Sulfhydryl (GSH) in Plasma
3.5. Total Antioxidant Status (TAS) in Plasma and CSF
3.6. Malondialdehyde (MDA) in Plasma and CSF
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | ICH Group | Control Group |
---|---|---|
Number of patients | 19 | 29 |
Sex, n [%] | ||
Male | 12 (63%) | 14 (48%) |
Female | 7 (37%) | 15 (52%) |
Age [years] | ||
Mean (SD) | 64.05 ± 10.99 | 57.52 ± 15.28 |
Mean volume of hemorrhageat day 1 [cm3] | 69.75 ± 57.4 | - |
Antioxidative/ Oxidative Parameters | ICH Group | Control Group | ||
---|---|---|---|---|
Day 1 | Day 3 | Day 7 | Day 1 | |
SOD (P) | [U/I] | |||
Mean (SD) | 1.18 ± 0.13 | 1.29 ± 0.26 | 1.22 ± 0.20 | 0.45 ± 0.49 |
SOD (CSF) | [U/I] | |||
Mean (SD) | 1.84 ± 0.25 | 2.58 ± 0.55 | 2.52 ± 1.67 | 0.94 ± 0.94 |
GSH-Px (P) | [U/I] | |||
Mean (SD) | 2127.23 ± 201.52 | 2033.84 ± 239.38 | 1720.0 ± 433.88 | 2312.72 ± 695.89 |
Free GSH (P) | [mg/L] | |||
Mean (SD) | 42.86 ± 8.15 | 47.33 ± 10.74 | 34.78 ± 9.14 | 61.34 ± 30.60 |
Total GSH (P) | [mg/L] | |||
Mean (SD) | 55.5 ± 7.59 | 57.65 ± 10.36 | 45.1 ± 6.9 | 69.57 ± 25.82 |
TAS (P) | [μmol/L] | |||
Mean (SD) | 80.25 ± 20.43 | 86.22 ± 17.82 | 62.60 ± 34.41 | 40.01 ± 31.4 |
TAS (CSF) | [μmol/L] | |||
Mean (SD) | 178.40 ± 20.80 | 114.87 ± 31.25 | 57.67 ± 57.37 | 220.99 ± 87.4 |
MDA (P) | [mg/L] | |||
Mean (SD) | 5.63 ± 2.43 | 5.44 ± 1.30 | 5.50 ± 1.73 | 6.67 ± 3.33 |
MDA (CSF) | [mg/L] | |||
Mean (SD) | 6.57 ± 3.60 | 9.04 ± 8.50 | 9.33 ± 3.71 | 7.92 ± 3.83 |
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Masomi-Bornwasser, J.; Kurz, E.; Frenz, C.; Schmitt, J.; Wesp, D.M.A.; König, J.; Lotz, J.; Ringel, F.; Kerz, T.; Krenzlin, H.; et al. The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage. Biomolecules 2021, 11, 1615. https://0-doi-org.brum.beds.ac.uk/10.3390/biom11111615
Masomi-Bornwasser J, Kurz E, Frenz C, Schmitt J, Wesp DMA, König J, Lotz J, Ringel F, Kerz T, Krenzlin H, et al. The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage. Biomolecules. 2021; 11(11):1615. https://0-doi-org.brum.beds.ac.uk/10.3390/biom11111615
Chicago/Turabian StyleMasomi-Bornwasser, Julia, Elena Kurz, Christina Frenz, Jan Schmitt, Dominik M. A. Wesp, Jochem König, Johannes Lotz, Florian Ringel, Thomas Kerz, Harald Krenzlin, and et al. 2021. "The Influence of Oxidative Stress on Neurological Outcomes in Spontaneous Intracerebral Hemorrhage" Biomolecules 11, no. 11: 1615. https://0-doi-org.brum.beds.ac.uk/10.3390/biom11111615