Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women
Abstract
:1. Introduction
2. Methods
2.1. Studies Extraction Process
2.2. Studies Derivation
3. Results of Studies on Hypovitaminosis D and MetSyn in Postmenopausal Women
3.1. RCT
3.2. Cross-Sectional Studies
4. Discussion
4.1. Role of Vitamin D in MetSyn
4.2. Serum Vitamin D, Estrogen, and MetSyn
5. Strengths and Limitations
6. Recommendations
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Reference and Location | Age, y (Mean ± SD or Range) | Study Design and n | Intervention | MetSyn Criteria | Assessment of Serum 25(OH)D (nmol/L) | Findings and Conclusions 2 |
---|---|---|---|---|---|---|
Ferreira et al., 2020, Brazil [28] | 58.8 ± 6.6 | RCT PMW, n = 160 Treatment group, n = 80 Control group, n = 80 9 month | Treatment group: Vitamin D supplementation, 1000 IU/d Control group: Placebo | Women meeting ≥ 3 of the following: WC > 88 cm TG ≥ 150 mg/dL HDL-C < 50 mg/dL BP ≥ 130/85 mmHg FBG ≥ 100 mg/dL | Sufficient, ≥75 Insufficient, 50–75 Deficient, <50 | Vitamin D supplementation: ↓TG ↓HOMA-IR ↓Risk of MetSyn ↓Risk of hypertriglyceridemia ↓Risk of hyperglycemia |
Schmitt et al., 2018, Brazil [24] | 45–75 | Cross-sectional PMW, n = 463 Vitamin D sufficient, n = 148 Vitamin D insufficient, n = 151 Vitamin D deficient, n = 164 | No intervention | Women meeting ≥ 3 of the following: WC > 88 cm TG ≥ 150 mg/dL HDL-C < 50 mg/dL BP ≥ 130/85 mmHg FBG ≥ 100 mg/dL | Sufficient, ≥75 Insufficient, 50–75 Deficient, <50 | Vitamin D insufficiency and deficiency were associated with: ↑MetSyn ↑TG ↑TC ↑HOMA-IR ↓HDL-C |
Jeenduan, et al., 2020, Thailand [30] | 62.7 ± 9.8 | Cross-sectional PMW, n = 340 Hypovitaminosis D (insufficient and deficient) n = 194 Vitamin D sufficient, n = 146 | No intervention | Women meeting ≥ 3 of the following: WC ≥ 80 cm TG ≥ 150 mg/dL HDL-C < 50 mg/dL BP ≥ 130/85 mmHg FBG ≥ 100 mg/dL | Sufficient, ≥75 Insufficient, 50–75 Deficient, <50 | Low serum 25(OH)D was associated with: ↑MetSyn ↑TG ↑TC ↑WC |
Chon et al., 2014,Korea [27] | <50–>70 | Cross-sectional PMW, n = 4364 Vitamin D tertile 1, n = 1454 Vitamin D tertile 2, n = 1456 Vitamin D tertile 3, n = 1454 | No intervention | Women meeting ≥ 3 of the following: WC ≥ 85 cm TG ≥ 150 mg/dL HDL-C < 50 mg/dL BP ≥ 130/85 mmHg FBG ≥ 100 mg/dL | Sufficient, ≥75 Insufficient, 50–75 Deficient, <50 | Vitamin D sufficiency was associated with: ↓BP ↓TG ↑HDL-C |
Mitra et al., 2016,India [36] | 51 ± 7.75 | Cross-sectional PMW, n = 64 Vitamin D sufficient, n = 16 Vitamin D insufficient, n = 15 Vitamin D deficient, n = 33 | No intervention | Women meeting ≥ 3 of the following: WC ≥ 80 cm TG ≥ 150 mg/dL HDL-C < 50 mg/dL BP ≥ 130/8 5 mmHg FBG ≥ 100 mg/dL | Sufficient, >75 Insufficient, 52.5–72.5 Deficient, <50 | No relation between serum 25(OH)D and cardiometabolic risk factors |
Srimani et al., 2017, Korea [31] | 45–70 | Cross-sectional PMW, n = 222 Vitamin D sufficient, n = 67 Vitamin D insufficient, n = 42 Vitamin D deficient, n = 113 | No intervention | Women meeting ≥ 3 of the following: WC ≥ 80 cm TG ≥ 150 mg/dL HDL-C < 50 mg/dL BP ≥ 130/85 mmHg FBG ≥ 110 mg/dL | Sufficient, 75–100 Insufficient, 50–75 Deficient, <50 | Serum 25(OH)D was associated with: ↑WC ↑FBG ↑TG ↑BP |
Dadonienėet al., 2018, Lithuania [33] | 57.9 ± 3.9 | Cross-sectional PMW, n = 210 Vitamin D sufficient, n = 84 Vitamin D deficient, n = 126 | No intervention | Women meeting ≥ 3 of the following: WC > 88 cm TG ≥ 150 mg/dL HDL-C < 50 mg/dL BP ≥ 130/85 mmHg FBG ≥ 100 mg/dL | Sufficient, ≥50 Deficient, <50 | No significant relation between serum 25(OH)D and vascular stiffness |
Chacko et al., 2011, USA [26] | 63.3 ± 7.5 | Cross-sectional/Case-control PMW, n = 292 Vitamin D tertile 1, n = 96 Vitamin D tertile 2, n = 94 Vitamin D tertile 3, n = 102 | No intervention Cases: 1 g calcium carbonate and 400 IU vitamin D3 Controls: Placebo | Women meeting ≥ 3 of the following: WC > 88 cm TG ≥ 150 mg/dL HDL-C < 50 mg/dL BP ≥ 130/85 mmHg FBG ≥ 100 mg/dL | 1st tertile, 26 2nd tertile, 43 3rd tertile, 70 | Serum 25(OH)D was associated with: ↓Adiposity ↓TG ↓TG to HDL-C ratio ↓MetSyn |
Alissa et al., 2001, Saudi Arabia [25] | 46–88 | Cross-sectional PMW, n = 300 Vitamin D insufficient and sufficient, n = 201 Vitamin D deficient, n = 99 | No intervention | Women with abdominal obesity (WC > 88 cm) with ≥2: TG ≥ 150 mg/dL HDL-C < 40 mg/dL BP ≥ 130/85 mmHg FBG ≥ 110 mg/dL | Insufficient and sufficient, ≥50 Deficient, <50 | Serum 25(OH)D was associated with: ↓TG ↓FBG ↓DBP |
Huang et al., 2019, China [29] | 63.7 ± 7.7 | Cross-sectional PMW, n = 616 Vitamin D sufficient, n = 192 Vitamin D insufficient, n = 312 Vitamin D deficient, n = 112 | No Intervention | Women meeting ≥ 3 of the following: WC ≥ 80 cm TG ≥ 150 mg/dL HDL-C < 50 mg/dL BP ≥ 130/85 mmHg FBG ≥ 100 mg/dL | Sufficient, >75 Insufficient, 50–75 Deficient, <50 | Serum 25(OH)D was associated with: ↑Estradiol ↓lipid profile ↓TC ↓TG ↓BP ↓FBG ↓MetSyn |
Chun et al., 2020, Korea [37] | 46.1 | Cross-sectional PMW, n = 8326 Sufficient, n = 1996 Insufficient, n = 6330 | No intervention | Women meeting ≥ 3 of the following: WC > 85 cm TG ≥ 150 mg/dL HDL-C < 50 mg/dL BP ≥ 130/85 mmHg FBG ≥ 100 mg/dL | Sufficient, ≥50 Deficient, <50 | PMW with deficient vitamin D had: ↑BMI ↑WC ↑FBG ↑TG ↓HDL-C |
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Abuhijleh, H.; Alkhatib, D.; Ganji, V. Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women. Healthcare 2022, 10, 2026. https://0-doi-org.brum.beds.ac.uk/10.3390/healthcare10102026
Abuhijleh H, Alkhatib D, Ganji V. Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women. Healthcare. 2022; 10(10):2026. https://0-doi-org.brum.beds.ac.uk/10.3390/healthcare10102026
Chicago/Turabian StyleAbuhijleh, Haya, Dana Alkhatib, and Vijay Ganji. 2022. "Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women" Healthcare 10, no. 10: 2026. https://0-doi-org.brum.beds.ac.uk/10.3390/healthcare10102026