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Photophysical and Electrocatalytic Properties of Rhenium(I) Triazole-Based Complexes
Article

Photophysical and Biological Properties of Iridium Tetrazolato Complexes Functionalised with Fatty Acid Chains

1
School of Molecular and Life Sciences, Curtin Institute for Functional Molecules and Interfaces, Curtin University, Kent Street, Bentley 6102, Australia
2
Metabolic Signalling Group, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Kent Street, Bentley 6102, Australia
3
Cancer Research Institute, University of South Australia, Adelaide 5005, Australia
4
Department of Industrial Chemistry “Toso Montanari”, University of Bologna, 40136 Bologna, Italy
*
Author to whom correspondence should be addressed.
Received: 28 January 2020 / Revised: 13 March 2020 / Accepted: 13 March 2020 / Published: 26 March 2020
(This article belongs to the Special Issue Photochemistry & Photophysics of Transition Metal Complexes)
Five cyclometalated Ir(III) tetrazolato complexes functionalised with fatty acid chains (octanoic, palmitic, stearic, palmitoleic, and oleic) have been synthesised. The fatty acids were chosen to evaluate the potential effect of the length and degree of unsaturation on the biological properties of the complexes for use as cellular imaging agents. The complexes were analysed in both organic and aqueous media to determine if the presence and nature of the fatty acid chains had a significant effect on their photophysical properties. The complexes display green–yellow emission in dichloromethane solutions with relatively long excited state decays, within the range 360–393 ns, and quantum yields between 5.4% and 6.7% (from degassed solutions). Temperature-dependent photophysical studies suggest that the emitting excited states of the complexes might be quenched by the thermal population of dark states. In water, the quantum yields drop within the range of 0.5%–2.4%, and the photophysical measurements are influenced by the variable degrees of aggregation. In general, the entire series displayed low cytotoxicity and relatively high photostability, which are favourable attributes in the design of cellular imaging agents. Images of live HeLa cells were obtained for all the complexes, but those functionalised with palmitic and stearic acids had limitations due the lower solubility conferred by the saturated aliphatic chains. The complexes were mainly detected within the endoplasmic reticulum. View Full-Text
Keywords: iridium; fatty acids; HeLa cells; confocal imaging; lipids iridium; fatty acids; HeLa cells; confocal imaging; lipids
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MDPI and ACS Style

Caporale, C.; Ranieri, A.M.; Paternoster, S.; Bader, C.A.; Falasca, M.; Plush, S.E.; Brooks, D.A.; Stagni, S.; Massi, M. Photophysical and Biological Properties of Iridium Tetrazolato Complexes Functionalised with Fatty Acid Chains. Inorganics 2020, 8, 23. https://0-doi-org.brum.beds.ac.uk/10.3390/inorganics8040023

AMA Style

Caporale C, Ranieri AM, Paternoster S, Bader CA, Falasca M, Plush SE, Brooks DA, Stagni S, Massi M. Photophysical and Biological Properties of Iridium Tetrazolato Complexes Functionalised with Fatty Acid Chains. Inorganics. 2020; 8(4):23. https://0-doi-org.brum.beds.ac.uk/10.3390/inorganics8040023

Chicago/Turabian Style

Caporale, Chiara, Anna M. Ranieri, Silvano Paternoster, Christie A. Bader, Marco Falasca, Sally E. Plush, Douglas A. Brooks, Stefano Stagni, and Massimiliano Massi. 2020. "Photophysical and Biological Properties of Iridium Tetrazolato Complexes Functionalised with Fatty Acid Chains" Inorganics 8, no. 4: 23. https://0-doi-org.brum.beds.ac.uk/10.3390/inorganics8040023

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