Hydroethanolic Extract of Defatted Buchholzia coriacea Seeds Alleviates Tamoxifen-Induced Hepatic Triglyceride Accumulation, Inflammation and Oxidative Distress in Rat
Abstract
:1. Introduction
2. Materials and Methods
2.1. Drug and Chemicals
2.2. Assay Kits and Antibodies
2.3. Buchholzia Coriacea Seeds
2.4. Experimental Animals
2.5. Experimental Design
2.6. Sample Collection
2.7. Biochemical Analysis and Immunohistochemistry
2.8. Histopathology
2.9. Statistical Analysis
3. Results
3.1. Variations in Body Weight of Rats
3.2. HEBCS Alleviates TMX-Induced Alteration in Liver Function Indices
3.3. HEBCS Alleviates TMX-Induced Alteration in Lipid Profile in Rats
3.4. HEBCS Alleviates TMX-Induced Increase in Hepatic Levels of Pro-Inflammatory Markers
3.5. HEBCS Alleviates a TMX-Induced Increase in Levels of Markers of Hepatic Oxidative Stress
3.6. HEBCS Alleviates TMX-Induced Depletion of Hepatic Antioxidants
3.7. HEBCS Alleviates TMX-Induced Alteration in Hepatic Histological Structure
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Ore, A.; Adeogun, A.I.; Akinloye, O.A. Hydroethanolic Extract of Defatted Buchholzia coriacea Seeds Alleviates Tamoxifen-Induced Hepatic Triglyceride Accumulation, Inflammation and Oxidative Distress in Rat. Medicines 2022, 9, 1. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines9010001
Ore A, Adeogun AI, Akinloye OA. Hydroethanolic Extract of Defatted Buchholzia coriacea Seeds Alleviates Tamoxifen-Induced Hepatic Triglyceride Accumulation, Inflammation and Oxidative Distress in Rat. Medicines. 2022; 9(1):1. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines9010001
Chicago/Turabian StyleOre, Ayokanmi, Abideen Idowu Adeogun, and Oluseyi Adeboye Akinloye. 2022. "Hydroethanolic Extract of Defatted Buchholzia coriacea Seeds Alleviates Tamoxifen-Induced Hepatic Triglyceride Accumulation, Inflammation and Oxidative Distress in Rat" Medicines 9, no. 1: 1. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines9010001