Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Nanoparticles of Metals
3.1.1. Silver Nanoparticles
3.1.2. Nanoparticles of Gold
3.1.3. Nanoparticles of Copper
3.2. Nanoparticles of Metal Oxides
3.2.1. Wound Dressings Containing Zinc Oxide Nanoparticles
3.2.2. Wound Dressings Containing Nanoparticles of Iron Oxides
3.2.3. Wound Dressings Containing Cerium Dioxide Nanoparticles
3.2.4. Wound Dressings Containing Titanium Dioxide Nanoparticles
3.2.5. Wound Dressings Containing Copper Oxide Nanoparticles
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Composition Code | PU Volume (mL) | HPS Volume (mL) | Water Dispersion AgNPs (mL) | Total Volume (mL) |
---|---|---|---|---|
AgNPs-0@NFs | 10 | 5 | 0 | 15 |
AgNPs-1@NFs | 9 | 5 | 1 | 15 |
AgNPs-2@NFs | 8 | 5 | 2 | 15 |
AgNPs-3@NFs | 7 | 5 | 3 | 15 |
Composition Code | ZOI Diameters (mm) | |||
---|---|---|---|---|
P. aeruginosa | E. faecalis | C. albicans | A. niger | |
AgNPs-0@NFs | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
AgNPs-1@NFs | 15 ± 0.20 | 13 ± 0.18 | 10 ± 0.16 | 11 ± 0.23 |
AgNPs-2@NFs | 21 ± 0.17 | 19 ± 0.12 | 17 ± 0.20 | 15 ± 0.15 |
AgNPs-3@NFs | 26 ± 0.23 | 24 ± 0.25 | 23 ± 0.23 | 21 ± 0.17 |
Ciprofloxacin | 12 ± 0.19 | 11 ± 0.25 | 8 ± 0.21 | 7 ± 0.14 |
Nanofiller | The Studied Characteristics of the Wound Dressings | Ref. |
---|---|---|
AgNPs | Antimicrobial activity | [22,23,24,25,26,27,28,29,30,31,32,33,34,35,36] |
Cytotoxicity analysis | [22,27,29,31,34,35] | |
Biocompatibility | [22,28,30] | |
Silver release measurements | [24,29,31,36] | |
In vivo wound healing activity | [27,30] | |
Swelling degree | [27,30,31] | |
Porosity | [29,31] | |
Mechanical properties | [25,28,29,31,35,36] | |
Immunohistochemical analysis | [27,30] | |
Water absorption | [29] | |
Water vapor transmission rate | ||
Air permeability | ||
Hemocompatibility | [30,31] | |
In vitro cell compatibility | [36] | |
AuNPs | Antimicrobial activity | [39,41] |
Cytotoxicity analysis | [41] | |
Biocompatibility | [39] | |
In vivo wound healing activity | [39] | |
Swelling degree | [39] | |
Mechanical properties | [39,41] | |
CuNPs | Antimicrobial activity In vivo wound healing activity Copper ion release tesr | [42] |
ZnO NPs | Antimicrobial activity | [44,47,48,49] |
Cytotoxicity analysis | [49,50] | |
In vivo wound healing activity | [45,48,49] | |
Swelling degree | [46,49] | |
Porosity | [49] | |
Mechanical properties | [46,47] | |
Water vapor transmission rate | [49] | |
Hemocompatibility | [46] | |
FeO NPs | Antimicrobial activity | [53] |
Porosity | ||
Water absorption | ||
Iron release | ||
Antidiabetic activity | ||
Fe3O4 NPs | Antimicrobial activity | [54] |
Cytotoxicity analysis | ||
Biocompatibility | ||
Swelling degree | ||
Porosity | ||
Mechanical properties | ||
Water vapor transmission rate | ||
CeO2 NPs | Antimicrobial activity | [56] |
Cytotoxicity analysis | ||
Evaluation of resistance genes expression in P. aeruginosa | ||
In vivo wound healing activity | [57] | |
Mechanical properties | ||
Water absorption | ||
In vitro cell proliferation test | ||
MWCNT_TiO2 | Antimicrobial activity | [59] |
Biocompatibility | ||
Mechanical properties | ||
CuO NPs | Mechanical properties Antimicrobial activity Biocompatibility | [62] |
Nanofiller | Effect on Cells | Advantage (+) Disadvantage (−) |
---|---|---|
AgNPs | Oxidative stress. Superoxide and hydroxyl radical generation | Strong antibacterial action (+) May cause allergies (−) Toxic to human skin keratinocyte cells (−) |
AuNPs | Presumably cause oxidative damage to bacteria | Nontoxic to human skin keratinocyte cells (+) Weak antimicrobial effect (−) |
CuNPs | Presumably copper ions bind the DNA molecules of a bacterial cell | Nontoxic to human skin keratinocyte cells (+) Lower antimicrobial effect vs. antibiotics (−) |
ZnO NPs | Electrostatic attraction of zinc ions to the bacterial cell membrane followed by release of the cell contents | Strong antibacterial action (+) Genotoxic to human epidermal cells (−) |
FeO NPs, Fe3O4 NPs | Penetrate through cell membrane and prevent transmembrane electron trnsfer | Strong antibacterial action (+) Toxic to human skin keratinocyte cells (−) |
CeO2 NPs | Oxidative stress on lipids and/or proteins in the plasma membrane through reduction in Ce4+ to Ce3+. | Strong antibacterial action (+) Low toxicity towards human skin keratinocyte cells (+) |
TiO2 NPs | Oxidative stress. Generation of two reactive oxygen intermediates—OH and H2O2. | Nontoxic to human skin keratinocyte cells (+) Weak antimicrobial effect (−) |
CuO NPs | Oxidative stress. Generation of four reactive oxygen intermediates—the superoxide oxygen radical, ·OH, H2O2, the singlet oxide. | Strong antibacterial action (+) Toxic to human skin keratinocyte cells (−) |
Nanoparticle | Year | No. of Publications | References |
---|---|---|---|
AgNPs | 2018 | 6 | [65,66,67,68,69,70] |
2019 | 4 | [71,72,73,74] | |
2020 | 12 | [75,76,77,78,79,80,81,82,83,84,85,86] | |
2021 | 2 | [23,27] | |
2022 | 13 | [22,24,25,26,28,29,30,31,32,33,34,35,36] | |
AuNPs | 2020 | 2 | [87,88] |
2021 | 2 | [39,41] | |
CuNPs | 2020 | 1 | [89] |
2021 | 1 | [42] | |
ZnO NPs | 2018 | 5 | [70,90,91,92,93] |
2019 | 4 | [94,95,96,97] | |
2020 | 2 | [85,98] | |
2021 | 2 | [44,46] | |
2022 | 5 | [45,47,48,49,50] | |
FeO NPs | 2021 | 1 | [53] |
Fe3O4 NPs | 2022 | 1 | [54] |
CeO2 NPs | 2019 | 1 | [99] |
2021 | 1 | [56] | |
2022 | 1 | [57] | |
TiO2 NPs | 2020 | 1 | [100] |
2022 | 1 | [59] | |
CuO NPs | 2021 | 1 | [62] |
Cu2O NPs | 2018 | 1 | [101] |
Lignin NPs | 2018 | 1 | [102] |
Silver zeolite NPs | 2018 | 1 | [103] |
ZrO2 NPs | 2020 | 1 | [104] |
Polymer | Year | No. of Publications | References |
---|---|---|---|
Chitosan and derivatives thereof | 2018 | 3 | [70,93,102] |
2019 | 4 | [71,72,74,94] | |
2020 | 8 | [75,76,81,82,86,88,89,100] | |
2021 | 4 | [27,42,46,53] | |
2022 | 6 | [25,34,35,47,48,49] | |
Polyvinyl alcohol | 2018 | 4 | [65,91,92,102] |
2019 | 3 | [73,94,96] | |
2020 | 5 | [81,83,84,87,88] | |
2021 | 3 | [39,42,53] | |
2022 | 4 | [24,25,26,49] | |
Cellulose and derivatives thereof | 2018 | 3 | [67,69,101] |
2020 | 2 | [85,104] | |
2022 | 2 | [33,59] | |
Polycaprolactone | 2020 | 1 | [104] |
2021 | 3 | [41,56,62] | |
2022 | 1 | [29] | |
Gelatin | 2020 | 1 | [80] |
2021 | 2 | [56,62] | |
2022 | 3 | [30,31,57] | |
Starch and derivatives thereof | 2020 | 1 | [83] |
2022 | 3 | [31,32,49] | |
Konjac glucomannan | 2018 | 1 | [68] |
2020 | 3 | [75,82,85] | |
Collagen | 2020 | 2 | [76,86] |
2022 | 2 | [23,59] | |
Silk fibroin | 2018 | 2 | [91,93] |
2019 | 1 | [71] | |
Sodium alginate and calcium alginate | 2019 | 1 | [97] |
2020 | 1 | [80] | |
2022 | 1 | [35] | |
Hyaluronic acid and derivatives thereof | 2020 | 1 | [89] |
2021 | 1 | [27] | |
2022 | 1 | [22] | |
Polyalkylene glycols | 2018 | 1 | [69] |
2019 | 1 | [72] | |
2020 | 2 | [98,100] | |
2022 | 1 | [29] | |
Keratin | 2019 | 1 | [95] |
2020 | 1 | [79] | |
Polylactic acid | 2022 | 2 | [28,57] |
κ-carrageenan | 2020 | 2 | [85,87] |
Polyurethane | 2022 | 2 | [28,32] |
Oxidized dextran | 2021 | 1 | [27] |
Polyvinylpyrrolidone | 2018 | 1 | [69] |
Agar | 2018 | 1 | [69] |
Poly(acrylic acid-co-itaconic acid) | 2018 | 1 | [90] |
Nylon 66 | 2018 | 1 | [66] |
Nylon 4/6 copolymer | 2018 | 1 | [103] |
Galacto-xyloglucan | 2020 | 1 | [77] |
Gum acacia and carbopol | 2020 | 1 | [78] |
HBV | 2019 | 1 | [99] |
Polyacrylonitrile | 2022 | 1 | [36] |
Heparin | 2021 | 1 | [39] |
Polyacrylic acid and polyallylamine hydrochloride | 2021 | [44] | |
Glycogen | 2022 | 1 | [48] |
Polyhydroxyethyl methacrylate | 2022 | 1 | [54] |
Quaternized chitin | 2022 | 1 | [28] |
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Yudaev, P.; Mezhuev, Y.; Chistyakov, E. Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects. Gels 2022, 8, 329. https://0-doi-org.brum.beds.ac.uk/10.3390/gels8060329
Yudaev P, Mezhuev Y, Chistyakov E. Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects. Gels. 2022; 8(6):329. https://0-doi-org.brum.beds.ac.uk/10.3390/gels8060329
Chicago/Turabian StyleYudaev, Pavel, Yaroslav Mezhuev, and Evgeniy Chistyakov. 2022. "Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects" Gels 8, no. 6: 329. https://0-doi-org.brum.beds.ac.uk/10.3390/gels8060329