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Article

Comparative Study of Contact Repulsion in Control and Mutant Macrophages Using a Novel Interaction Detection

1
School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK
2
Randall Centre for Cell & Molecular Biophysics, King’s College London, London SE1 1UL, UK
3
GiCentre, Departmen t of Computer Science, School of Mathematics, Computer Science and Engineering, City, University of London, London EC1V 0HB, UK
*
Authors to whom correspondence should be addressed.
This paper is an extended version of our paper published in: Solí s-Lemus, J.A.; Sánchez-Sánchez, B.J.; Marcotti, S.; Burki, M.; Stramer, B.; Reyes-Aldasoro, C.C. Comparison of Interactions Between Control and Mutant Macrophages. In Communications in Computer and Information Science, Proceedings of the Medical Image Understanding and Analysis (MIUA), Liverpool, UK, 11–13 July 2019; Zheng, Y., Williams, B.M., Chen, K., Eds.; Springer: Cham, Switzerland, 2019; pp. 470–477.
Received: 31 March 2020 / Revised: 1 May 2020 / Accepted: 15 May 2020 / Published: 20 May 2020
(This article belongs to the Special Issue MIUA2019)
In this paper, a novel method for interaction detection is presented to compare the contact dynamics of macrophages in the Drosophila embryo. The study is carried out by a framework called macrosight, which analyses the movement and interaction of migrating macrophages. The framework incorporates a segmentation and tracking algorithm into analysing the motion characteristics of cells after contact. In this particular study, the interactions between cells is characterised in the case of control embryos and Shot mutants, a candidate protein that is hypothesised to regulate contact dynamics between migrating cells. Statistical significance between control and mutant cells was found when comparing the direction of motion after contact in specific conditions. Such discoveries provide insights for future developments in combining biological experiments with computational analysis. View Full-Text
Keywords: cell segmentation; cell tracking; macrophages; cell shape; contact analysis cell segmentation; cell tracking; macrophages; cell shape; contact analysis
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MDPI and ACS Style

Solís-Lemus, J.A.; Sánchez-Sánchez, B.J.; Marcotti, S.; Burki, M.; Stramer, B.; Reyes-Aldasoro, C.C. Comparative Study of Contact Repulsion in Control and Mutant Macrophages Using a Novel Interaction Detection. J. Imaging 2020, 6, 36. https://0-doi-org.brum.beds.ac.uk/10.3390/jimaging6050036

AMA Style

Solís-Lemus JA, Sánchez-Sánchez BJ, Marcotti S, Burki M, Stramer B, Reyes-Aldasoro CC. Comparative Study of Contact Repulsion in Control and Mutant Macrophages Using a Novel Interaction Detection. Journal of Imaging. 2020; 6(5):36. https://0-doi-org.brum.beds.ac.uk/10.3390/jimaging6050036

Chicago/Turabian Style

Solís-Lemus, José A.; Sánchez-Sánchez, Besaiz J.; Marcotti, Stefania; Burki, Mubarik; Stramer, Brian; Reyes-Aldasoro, Constantino C. 2020. "Comparative Study of Contact Repulsion in Control and Mutant Macrophages Using a Novel Interaction Detection" J. Imaging 6, no. 5: 36. https://0-doi-org.brum.beds.ac.uk/10.3390/jimaging6050036

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