Ocular Autonomic Nervous System: An Update from Anatomy to Physiological Functions
Round 1
Reviewer 1 Report
The authors did a good job in describing the basic ocular nervous system. Specifically, recommendations for further investigation was greatly appreciated.
Author Response
Thank you for your comments.
Reviewer 2 Report
See minor corrections:
- Page 1, line 23: “intraocular muscles” better than “muscles”.
- Page 2, line 52: place quotation before the point.
- Page 2, line 59: place quotation before the point.
- Page 2, line 63: Place quotation before the point.
- More quotations after the point identified.
- Page 6, line 227: delete “anterior” add. Conjunctiva.
- Page 6, line 237: space before via.
- Page 8, line 344: space after EWn.
- Page 7, line 354: point and space after (148).
- Page 12, line 434: exits the eye.
- Page 12, line 437: delete “immense”.
- Page 12, line 461: add “of the ciliary body” after Non pigmented.
- Page 14, line 497: ”and” leaves…
- Page 14, line 500: delete “recently”. A 1993 (!) observation is not recent.
- Page 15, line 551: better “IOP regulation”.
Author Response
In Page 1, line 23, “muscles” has been changed to “intraocular muscles”
In page 6, line 228, “anterior” has been deleted and “conjunctiva” has been added.
In page 8, line 347, space after “EWn” has been deleted.
In page 8, line 356, the point and space after “[148]” has been deleted.
In page 13, line 437, “exists in” has been changed to “exits”.
In page 13, line 440, “immense” has been deleted.
In page 13, line 464, “of the ciliary body” has been added after “non pigmented epithelial cells”
In page 15, line 500, “or” has been changed to “and”.
In page 15, line 503, “recently” has been deleted.
In page 16, line 554, “IOP” has been changed to “IOP regulation”.
In page 11, figure 2 has been changed since the ciliary ganglion was abbreviated as “GC” by mistake. And the figure legend has been corrected as well.
The references have been reimported since some of them were with wrong format.
Reviewer 3 Report
This is a comprehensive and interesting review of the subject. It would be good if the authors present some new knowledge / recent developments in this field for example gained in the recent 10 years. Otherwise, it looks more like a chapter than an article. The majority of the content can be found in textbooks - the article should present and discuss some recent progress in knowledge and future applications. How this knowledge can be used for future diagnostics/ treatment of different eye disorders is missing here. Please check ref. 17.
Author Response
Thanks for your comments. Indeed, the anatomy of autonomic nervous system related to the eye was also discussed in many other articles and there are few progresses in afferent and efferent autonomic nerves. However, it seems to be fundamental since the basic anatomy could help the reader quickly understand the whole review.
There are still some more recently progresses in physiology. For example, the location of the premotor neurons controlling lens accommodation (May & Gamlin, 2020; May, Warren, Bohlen, Barnerssoi, & Horn, 2016), the regulation of tear secretion (Jin et al., 2020). And the effects of autonomic nerves on trabecular meshwork and Schlemm’s canal as well as choroid were frequently observed and elucidated in recent years (Chen et al., 2019; Li et al., 2021; Luo et al., 2020; Nickla & Schroedl, 2019; Sun et al., 2020). The innervation of autonomic nervous system seems pretty complicated and some current researches are inconsistent. There is still a long way to go into clinical applications. Just like the sympathectomy, which was considered a valid treatment of glaucoma initially and finally abandoned due to its uncertain effects (Feibel, 2015).
The ref.17 has been revised.
Round 2
Reviewer 3 Report
The ms is not improved significantly. There are many present approaches to use ANS agents in ophthalmology, including the treatment of myopia with atropine or presbyopia with pilocarpine to name a few. These topics should be discussed both in terms of their mechanism of action and long-term safety.
Author Response
Please see the attachment.
Author Response File: 
Author Response.docx
