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Article

Modelling the Use of Vaccine and Wolbachia on Dengue Transmission Dynamics

Department of Mathematics, Faculty of Sciences and Engineering, University of Nusa Cendana, Kupang 85361, Indonesia
Trop. Med. Infect. Dis. 2020, 5(2), 78; https://0-doi-org.brum.beds.ac.uk/10.3390/tropicalmed5020078
Received: 31 March 2020 / Revised: 30 April 2020 / Accepted: 6 May 2020 / Published: 13 May 2020
(This article belongs to the Special Issue Epidemiology of Dengue: Past, Present and Future (Volume II))
The use of vaccine and Wolbachia has been proposed as strategies against dengue. Research showed that the Wolbachia intervention is highly effective in areas with low to moderate transmission levels. On the other hand, the use of vaccine is strongly effective when it is implemented on seropositive individuals and areas with high transmission levels. The question that arises is could the combination of both strategies result in higher reduction in the number of dengue cases? This paper seeks to answer the aforementioned question by the use of a mathematical model. A deterministic model in the presence of vaccine and Wolbachia has been developed and analysed. Numerical simulations were presented and public health implications were discussed. The results showed that the performance of Wolbachia in reducing the number of dengue cases is better than that of vaccination if the vaccine efficacy is low, otherwise, the use of vaccine is sufficient to reduce dengue incidence and hence the combination of Wolbachia and vaccine is not necessary. View Full-Text
Keywords: mathematical model; dengue; vaccine; Wolbachia mathematical model; dengue; vaccine; Wolbachia
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MDPI and ACS Style

Ndii, M.Z. Modelling the Use of Vaccine and Wolbachia on Dengue Transmission Dynamics. Trop. Med. Infect. Dis. 2020, 5, 78. https://0-doi-org.brum.beds.ac.uk/10.3390/tropicalmed5020078

AMA Style

Ndii MZ. Modelling the Use of Vaccine and Wolbachia on Dengue Transmission Dynamics. Tropical Medicine and Infectious Disease. 2020; 5(2):78. https://0-doi-org.brum.beds.ac.uk/10.3390/tropicalmed5020078

Chicago/Turabian Style

Ndii, Meksianis Z. 2020. "Modelling the Use of Vaccine and Wolbachia on Dengue Transmission Dynamics" Trop. Med. Infect. Dis. 5, no. 2: 78. https://0-doi-org.brum.beds.ac.uk/10.3390/tropicalmed5020078

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