The Zika Virus Individual Participant Data Consortium: A Global Initiative to Estimate the Effects of Exposure to Zika Virus during Pregnancy on Adverse Fetal, Infant, and Child Health Outcomes

Round 1

Reviewer 1 Report

Well written. No major modification to add.

Major work to be done in the field of ZIKA. I thus support the publication.

Broader review in the field might have been mentioned in the introduction.

Reviewer 2 Report

The present communication from Zika Virus Individual Participant Data (IPD) Consortium announce the initiative by research groups from different countries of share individual participant data meta-analysis from 52 cohort study of pregnant woman and babies exposed to ZIKV.

The global data integration efforts presented by the consortium represents a substantial advance in understanding different aspects of the ZIKV epidemic and its outcomes.

Thus, the study can be considered of high relevance

Reviewer 3 Report

This is a communication on the creation of the Zika Virus Individual Participant Data Consortium, a global collaboration to address outstanding questions in ZIKV epidemiology through conducting an individual participant data meta-analysis (IPD-MA).

The objectives of the Consortium have been presented and are very relevant. The data comes from surveillance systems and longitudinal studies. A figure on the size and diversity of participating countries was presented.

The IPD-MA is an important initiative for strengthening data sharing is a central component of global health security and outbreak response.

The creation of the IPD-MA is very timely, even more so at a time when the COVID-19 pandemic showed the global fragility in the face of the emergence of pathogens. It emphasizes the need for a continuous global agenda on the topic and not punctual as it has been treated so far.