An Italian Registry on Risk Factors for Venous Thromboembolism in Blood Donors Clinicaltrials. Gov: Nct03282747 †
by
,
Elvira Grandone
1,*
,
Angelo Ostuni
2,
Lazzaro di Mauro
3,
Nadia Coffetti
4,
Anna Turrini
5,
Giobatta Cavallero
6,
Patrizia Vergura
1,
Filomena Cappucci
1,
Antonio de Laurenzo
1,
Michela Villani
1,
Nicola Di Renzo
7,
Alberto Tosetto
8 and
Maurizio Margaglione
9 1
Thrombosis and Haemostasis Centre, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo, Italy
2
Transfusion Medicine, Azienda Ospedaliero-Universitaria Consorziale, Policlinico di Bari, Piazza Giulio Cesare, 70124 Bari, Italy
3
Clinical Laboratory and Transfusion Medicine, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo, Italy
4
Immunology and Transfusion Medicine, Azienda Ospedaliera Bolognini, ASST Bergamo Est, via Marconi, 38, 24068 Seriate, Italy
5
Clinical Laboratory and Transfusion Medicine, Ospedale “Sacro Cuore-Don Calabria”, via don A. Sempreboni, 5, 37024 Negrar, Italy
6
Internal Medicine, Ospedale “Santa Croce e Carle”, via Michele Coppino, 26, 12100 Cuneo, Italy
7
Haematology, Ospedale Vito Fazzi, Piazzetta Muratore, 73100 Lecce, Italy
8
Haematology Unit, Ospedale S. Bortolo, via Ferdinando Rodolfi, 37, 36100 Vicenza, Italy
9
Medical Genetics, University of Foggia, viale Pinto, 71100 Foggia, Italy
*
Author to whom correspondence should be addressed.
†
Presented at the 25th Biennial International Congress on Thrombosis, Venice, Italy, 23–26 May 2018.
Proceedings 2018, 2(9), 532; https://0-doi-org.brum.beds.ac.uk/10.3390/proceedings2090532
Published: 25 July 2018
(This article belongs to the Proceedings of The 25th Biennial International Congress on Thrombosis)
Abstract
:A registry-based study to evaluate prevalence of common risk factors for vein thrombosis among healthy subjects.
1. Background
The impact of several risk factors in the occurrence of venous thrombosis with/without pulmonary embolism, collectively called venous thromboembolism (VTE), is well known in patients who previously suffered from VTE [1]. Little is known about their impact in healthy population.
2. Materials and Methods
We evaluated the incidence of risk factors for VTE in a population of Italian blood donors: BMI, blood group, previous transfusions, plaster cast, previous surgery, gross veins, history of venous thrombosis and/or use of anticoagulation drugs. The study started in 1 June 2017. Information were collected by means of a self-administered questionnaire. All analyses were performed using SPSS version 11.0. Odds ratios (ORs) for risk factors for VTE were calculated. Proportions were compared using Fisher exact test or c2-test where appropriate. Adjusted OR and 95% confidence interval (CI) were calculated using logistic regression models that controlled for potential confounding variables such as age, BMI, blood group, surgery, plaster cast, immobilization, transfusion.
3. Results
Until November 20th, 5506 questionnaires were collected. 4120 (75.3%) men and 1354 (24.7%) women were consecutively enrolled. Mean age (+SD) was 42.7 + 12.3 yrs in men, 38.4 + 13.4 yrs in women (p < 0.001), BMI was 26.05 + 4.14 in men and 24.5 + 4.93 in women (p < 0.001). Group 0 was observed in 48% and non-0 in 52%. With regards to smoking habits, no significant difference was observed between men and women with the exception for ex-smokers (143/1354 women vs. 786/4120 men, p < 0.001). A history of vein thrombosis (likely superficial thromboses) was referred by 36 (0.7%) subjects, gross veins by 320/5442 (5.9%), previous surgery by 1896/5478 (34.6%). Previous transfusion was reported by 73/5019 (1.5%) individuals and 236/5268 (4.5%) had used at least once anticoagulation drugs. At univariate analysis, gross veins, bed rest/plaster cast, surgery and transfusions were associated with vein thrombosis. At logistic regression (see Table 1), a significantly and independent association was found between VTE and gross veins (OR: 15.8, 95%CI 7.7–32.6), plaster cast/bed rest (OR: 2.3, 95% CI 1.0–5.3) and transfusion (OR: 5.1, 95% CI 1.3–19.5).
4. Discussion
To the best of our knowledge, this is the first study in a large series of blood donors aimed at investigating the distribution of risk factors for VTE. We find that gross veins, plaster cast/bed rest and previous transfusions are independent risk factors for VTE. Further studies that can confirm and extend these findings are warranted.
Bullet points:
- Assessment of risk factors for VTE is mostly limited to VTE-diagnosed subjects
- Information on risk factors for VTE in healthy subjects are lacking
- Transfusions could confer the risk for VTE
Conflicts of Interest
The authors declare no conflict of interest.
Reference
- Seeley, R.R.; Stephens, T.D.; Tate, P. Anatomy and Physiology, 4th ed.; The McGraw Hill Companies Inc.: New York, NY, USA, 1998; p. 1098. [Google Scholar]
Table 1.
Logistic regression.
| Variables | OR | 95% CI |
|---|---|---|
| Gross veins | 15.8 | 7.7–32.6 |
| Plaster cast/Bed rest | 2.3 | 1.0–5.3 |
| Transfusions | 5.1 | 1.3–19.5 |
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MDPI and ACS Style
Grandone, E.; Ostuni, A.; Mauro, L.d.; Coffetti, N.; Turrini, A.; Cavallero, G.; Vergura, P.; Cappucci, F.; Laurenzo, A.d.; Villani, M.; et al. An Italian Registry on Risk Factors for Venous Thromboembolism in Blood Donors Clinicaltrials. Gov: Nct03282747. Proceedings 2018, 2, 532. https://0-doi-org.brum.beds.ac.uk/10.3390/proceedings2090532
AMA Style
Grandone E, Ostuni A, Mauro Ld, Coffetti N, Turrini A, Cavallero G, Vergura P, Cappucci F, Laurenzo Ad, Villani M, et al. An Italian Registry on Risk Factors for Venous Thromboembolism in Blood Donors Clinicaltrials. Gov: Nct03282747. Proceedings. 2018; 2(9):532. https://0-doi-org.brum.beds.ac.uk/10.3390/proceedings2090532
Chicago/Turabian StyleGrandone, Elvira, Angelo Ostuni, Lazzaro di Mauro, Nadia Coffetti, Anna Turrini, Giobatta Cavallero, Patrizia Vergura, Filomena Cappucci, Antonio de Laurenzo, Michela Villani, and et al. 2018. "An Italian Registry on Risk Factors for Venous Thromboembolism in Blood Donors Clinicaltrials. Gov: Nct03282747" Proceedings 2, no. 9: 532. https://0-doi-org.brum.beds.ac.uk/10.3390/proceedings2090532
