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Article

Expression of Hypoxia-Inducible Factors in Different Stages of Pancreatic Tumor Progression

1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju 52727, Korea
2
Department of Internal Medicine, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
3
Strelitz Diabetes Center, Endocrine & Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA 23510, USA
4
Department of Internal Medicine, Eastern Virginia Medical School, 855 W Brambleton Ave, Norfolk, VA 23510, USA
*
Author to whom correspondence should be addressed.
Received: 11 August 2020 / Revised: 10 October 2020 / Accepted: 12 October 2020 / Published: 15 October 2020
Background: Early diagnosis in pancreatic cancer is key for improving prognosis. Hypoxia plays a critical role in tumor progression. Thus, an evaluation of associations between pancreatic tumor progression and markers of hypoxia is needed. Methods: We assessed the expression of hypoxia-inducible factors (HIF-1α and HIF-2α) by immuno-histochemical staining from 29 subjects with the following: pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), neuroendocrine tumor (NET), and pancreatic ductal adenocarcinoma (PDAC) and compared it to the expression in non-tumor samples. Results: Expression of HIF-1α increased significantly from PanIN (3.01 ± 0.17) to IPMN (7.63 ± 0.18), NET (9.10 ± 0.23) and PDAC samples (11.06 ± 0.15, p < 0.0001). Similar findings were observed for HIF-2α (p < 0.0001)}. A strong correlation between HIF-1α and HIF-2α expression was demonstrated (R2 = 0.8408, p < 0.0001). Conclusions: This data suggest that HIF-1α and HIF-2α may play a role in the progression from PanIN through PDAC. Further studies are necessary to confirm these findings and determine the effect of HIFs abrogation on tumor progression that can lead to novel therapies. View Full-Text
Keywords: hypoxia; pancreatic adenocarcinoma; neuroendocrine tumor; pancreatic intraepithelial neoplasia; intraductal papillary mucinous neoplasm hypoxia; pancreatic adenocarcinoma; neuroendocrine tumor; pancreatic intraepithelial neoplasia; intraductal papillary mucinous neoplasm
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MDPI and ACS Style

Jung, J.H.; Sosnowska, D.; Weaver, J.; Parson, H.K.; Casellini, C.M.; Vinik, A.I. Expression of Hypoxia-Inducible Factors in Different Stages of Pancreatic Tumor Progression. Reports 2020, 3, 30. https://0-doi-org.brum.beds.ac.uk/10.3390/reports3040030

AMA Style

Jung JH, Sosnowska D, Weaver J, Parson HK, Casellini CM, Vinik AI. Expression of Hypoxia-Inducible Factors in Different Stages of Pancreatic Tumor Progression. Reports. 2020; 3(4):30. https://0-doi-org.brum.beds.ac.uk/10.3390/reports3040030

Chicago/Turabian Style

Jung, Jung H., Danuta Sosnowska, Jessica Weaver, Henri K. Parson, Carolina M. Casellini, and Aaron I. Vinik. 2020. "Expression of Hypoxia-Inducible Factors in Different Stages of Pancreatic Tumor Progression" Reports 3, no. 4: 30. https://0-doi-org.brum.beds.ac.uk/10.3390/reports3040030

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