Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis
Abstract
:1. Background
2. Cigarette Smoke and ALS
3. CS-Induced ALS Pathogenesis: Direct Pathways
3.1. Oxidative Stress
3.2. Neuroinflammation
3.3. Immunometabolism
3.4. Epigenetic Alterations
4. CS-Induced ALS Pathogenesis: Indirect Pathways
4.1. Blood–Spinal Cord Barrier Dysfunction
4.2. Cell Influx
4.3. Microbiome
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Source | Study Design | Participants with ALS included in Patient Population | Findings |
---|---|---|---|
Weisskopf et al., 2004 [24] | Prospective cohort study | 330 | Current smokers had an increased risk of ALS and ALS-related death in females but not males, no increased risk associated with pack years or cigarettes smokes per day. |
Fang et al., 2006 [16] | Prospective cohort study | 160 | No strong evidence was found between smokers and ALS risk. |
Sutedja et al., 2007 [25] | Case–control study | 364 | Current smokers had an increased risk of ALS when compared to non-smokers. |
Gallo et al., 2009 [12] | Prospective cohort study | 118 | Pack years associated with increased risk of ALS, current smokers had greater risk of ALS-related mortality, number of years since quitting associated with decreased ALS risk. |
Alonso et al., 2010 [26] | Population-based case–control study | 1143 | Female ever smokers a were associated with an increased risk of ALS but not men, smoking is a predictor in female ALS-related mortality not men. |
Wang et al., 2011 [13] | Pooled analysis of 5 prospective cohorts | 832 | Ever smokers had an increased risk of developing ALS when compared to never smokers, mean number of daily cigarettes smoked and smoking duration were positively associated with ALS, younger age of smoking initiation associated with higher risk of ALS. |
de Jong et al., 2012 [27] | Population-based case–control study | 494 | Current smokers had an increased risk of ALS and a worse prognosis following ALS diagnosis with a shorter survival. |
Pamphlett et al., 2012 [17] | Case–control study | 631 | Smoking status, pack years and age when smoking began were not associated with an increased risk of ALS. |
Calvo et al., 2016 [14] | Population-based cohort study | 650 | Patients who were currently smoking had a younger age of ALS onset, current and former smokers had a significantly shorter median survival compared to never smokers, smoking status significantly correlated with mean monthly decline in ALS disease severity. |
Zhan et al., 2019 [15] | Mendelian randomisation population-based study | 12,577 | Ever smokers had a higher risk for ALS when compared to never smokers. |
Peters et al., 2020 [21] | Population-based case–control study | 1410 | Smoking pack years positively associated with ALS risk when compared to never smokers, increased risk associated strongly with smoking duration rather than smoking intensity, inverse relationship observed between ALS risk and time-since-quitting smoking. |
Opie-Martin et al., 2020 [28] | Retrospective case–control study | 202 | Weak association between current smoking and risk of ALS. |
Opie-Martin et al., 2020 [29] | Mendelian randomisation population-based study | 20,806 | No strong evidence was found between ever smokers and ALS risk. |
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Menounos, S.; Hansbro, P.M.; Diwan, A.D.; Das, A. Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis. NeuroSci 2021, 2, 120-134. https://0-doi-org.brum.beds.ac.uk/10.3390/neurosci2020008
Menounos S, Hansbro PM, Diwan AD, Das A. Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis. NeuroSci. 2021; 2(2):120-134. https://0-doi-org.brum.beds.ac.uk/10.3390/neurosci2020008
Chicago/Turabian StyleMenounos, Spiro, Philip M. Hansbro, Ashish D. Diwan, and Abhirup Das. 2021. "Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis" NeuroSci 2, no. 2: 120-134. https://0-doi-org.brum.beds.ac.uk/10.3390/neurosci2020008