Psychiatry Int., Volume 3, Issue 3 (September 2022) – 5 articles

Anorexia nervosa (AN) is an eating disorder characterized by restrictive eating and significant weight loss. In the course of AN, changes are observed in appetite regulation, including orexigenic ghrelin and potentially anorexigenic obestatin. The study aimed to determine if any changes in serum ghrelin and obestatin levels during treatment of AN are observed, while investigating the correlations between these peptides and the severity of disturbed eating attitudes, depression, and anxiety. Thirty adolescent inpatients with AN (examined twice: before hospitalization treatment AN-BT and after treatment AN-AT) and thirty healthy age- and height-matched girls (CG) participated in the study. Anthropometric, serum ghrelin and obestatin concentrations and psychometric evaluations (Eating Attitudes Test 26 Item-EAT-26, Beck Depression Inventory-BDI, Hamilton Depression Rating Scale-HDRS, and Yale Brown Obsessive-Compulsive Scale-Y-BOCS) were performed. The study revealed significantly higher ghrelin and obestatin levels in AN-BT than in AN-AT. A trend toward lower levels during treatment provided partial normalizations. Analyzing correlations in the AN-BT vs. CG group, correlations of peptides with EAT-26, BDI, and HDRS scores were detected. These results suggest a potential role for ghrelin and obestatin in the context of defense mechanisms regulating appetite and body weight in the course of AN and in terms of psychopathological changes co-occurring with this eating disorder. Full article

The coronavirus disease (COVID-19) pandemic and the social distancing resulting thereof are having a great impact on psychological well-being. Studies investigating resilience found that it impacts mental health during crises. This study aimed to evaluate the influence of pre-crisis temperament on resilience in individuals with bipolar disorder during the COVID-19 pandemic. An online survey was conducted in Austria between April and June 2020, including 36 individuals with bipolar disorder and 39 healthy controls. Resilience was assessed with the 13-item resilience scale, and temperament was measured with the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire (TEMPS-A). The bipolar disorder group showed lower resilience than the control group, and scored higher on the TEMPS-A for depressive, cyclothymic, and anxious temperaments. Resilience could be predicted by anxious temperament in individuals with bipolar disorder, and correlated negatively with depressive symptoms in both groups. The results suggest that anxious temperament influences the resilience of individuals with bipolar disorder, likely more than temporary hardships, such as the first months of the COVID-19 crisis. It is therefore important to improve the resilience of individuals with bipolar disorder not only by short-term interventions, but by strengthening resilience and reducing anxious temperament in the long term. Full article

Stimulants are effective in treating attention-deficit/hyperactivity disorder (ADHD). Psychiatrist Charles Bradley first made this discovery in 1937 when he found that children treated with amphetamines showed improvements in school performance and behavior. Between 1995 and 2008, stimulants to treat ADHD increased six-fold among American adults and adolescents at an annual rate of 6.5%. Stimulants without a prescription, known as nonmedical use or misuse, have also increased. The highest rates of nonmedical prescription drug misuse in the United States are seen most notably in young adults between 18 and 25 years, based on data from the Substance Abuse and Mental Health Services Administration in 2021. Aside from undergraduate students, nonmedical prescription stimulant use is prevalent among medical students worldwide. A recent literature review reported the utilization of stimulants without a prescription in 970 out of 11,029 medical students. The percentages of medical students across the country misusing stimulants varied from 5.2% to 47.4%. Academic enhancement, reported in 50% to 89% of college students with stimulant misuse, is the most common reason for nonmedical stimulant use. With the increasing use of stimulants among adolescents and adults, it is unclear what long-term outcomes will be since little data are available that describe differences in how side effects are experienced for prescribed and non-prescribed users. The present narrative review focuses on these adverse effects in this population and the reasonings behind misuse and nonmedical use. Full article

Aim: to clarify the association between political party affinity and fear of conventional and nuclear war in Germany. Methods: data were used from a nationally representative online survey (in terms of age bracket, sex and state; n = 3091 individuals; mid-March 2022). Multiple linear regressions were used to investigate the association between political party affinity and fear of conventional and nuclear war in Germany, adjusting for several covariates. Results: while, for example, individuals who had an affinity with the Social Democratic Party (SPD) of Germany reported the highest frequency of severe fear of a conventional war (58.0%), individuals who had an affinity with the Left Party (Die Linken, left-wing) reported a somewhat lower frequency of severe fear (48.2%) and individuals who had an affinity with the Alternative for Germany (AFD, right-wing) reported the lowest frequency (43.7%). Regressions showed that—compared to individuals who had an affinity with the SPD—individuals who had an affinity with the Free Democratic Party (FDP, liberal) and particularly individuals who had an affinity with the Alternative for Germany (AFD) reported a markedly lower fear of war (both fear of a conventional war and fear of a nuclear war). Conclusion: our study showed some interesting associations between political party affinity and fear of war in Germany. This knowledge may assist in characterising individuals at risk for higher levels of fear of war. Full article

The COVID-19 pandemic has not only had an impact on the health of many people, but also on politics, the economy, and everyday life at large. It has been shown that some people respond with anxiety and depression, which is not surprising. Another reaction in the context of COVID-19 is embittered fights and disruptions between family members, friends, and neighbors, but also problems on a societal and political level, mutual public insults, political demonstrations, and even aggressive outbursts with a high number of participants. This calls for a separate explanation. One trigger may be embitterment, an emotion known to anybody in reaction to injustice, humiliation, and breach of trust, in association with helplessness. It comes along with a nagging desire to fight back and is usually accompanied by aggressive fantasies and combatively impulses towards the wrongdoer. This emotion also spreads indiscriminately to other people and the world. There are few initial studies which show that there is a significant increase in the rate of embitterment during the COVID-19 pandemic. Increased embitterment was related to financial losses, concern about restricted societal freedom, job insecurity, oppositional attitudes, helplessness, dissatisfaction with life, and inclination to join anti-COVID-19 demonstrations. These findings suggest that it is important to foster resilience against stressors, be it because of the virus itself, restrictions in daily freedom, negative comments by other persons, or imbalanced press releases. Of importance is also to abstain from insulting comments towards people who do not follow the mainstream, to allow adjustment of rules to given situations, and to take people along by listening to their grievances, instead of leaving demonstrations on the street as the only method to voice concerns. Full article