Functions of Leukocyte Calcium Channels

Dear Colleagues,

We cordially invite you to submit experimental papers, review articles, or communications for an upcoming issue of Biology, which Frederic and I are supporting as guest editors.

In the last two decades, the Ca²⁺ field of leukocytes has been revolutionized by the discovery of the Orai/STIM protein couple. Under stimulation, leukocytes mobilized cytosolic Ca²⁺ by releasing Ca²⁺ ions from the endoplasmic reticulum (ER), allowing the activation of the ER proteins STIM, which interact with plasma membrane pore-forming proteins Orai1, inducing a massive Ca²⁺ influx known as the store-operated calcium entry (SOCE). Mutations of STIM or Orai genes are associated with immune disorders. This process is finely tuned in the cell, in particular by the +TIP (microtubule plus-end TrackIng Protein) EB1 which interacts directly with STIM1 at dynamic contacts between ER and microtubule plus ends, delaying its delivery to the plasma membrane and thus reducing Ca²⁺ influx. Beside the SOCE, other Ca²⁺ channels exist which can be activated by other stimulation, like adrenergic receptors or TRP channels.

This issue of Biology will cover a selection of novel research and review articles about SOCE and other Ca²⁺ influx in the different types of leukocytes, and their role in the leukocyte physiology. The articles will focus on Ca²⁺ homeostasis in physiology and pathophysiology, STIM/Orai couples, STIM and Orai isoforms, STIM and microtubules, and other leukocyte Ca²⁺ channels.

Dr. Olivier Dellis
Dr. Frederic M. Coquelle
Guest Editors

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• Ca²⁺ channels
• Leukocytes
• Ca²⁺ homeostasis
• STIM/Orai proteins
• Adrenergic receptor
• TRP channels
• Cytoskeleton
• ER-Microtubules contacts