New Insights into Cytochrome P450s, 2nd Edition
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 31 December 2024 | Viewed by 27
Special Issue Editor
Interests: enzymology; chemical biology; protein structure and dynamics; cytochrome P450; AlphaFold2
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cytochrome P450s form one of the most populated superfamilies of enzymes in nature. A recent search in the PDB with P450 as a keyword retrieved thousands of entries and 740,283 (highly redundant) entries in the UniProtKB database. Since their discovery in the late 1950s, these heme–thiolate proteins have been found in both prokaryotes and eukaryotes, with a few exceptions, such as E. coli. Recently, cytochrome P450s have also been spotted in viruses. Identification and functional studies have revealed that some P450s are specific to one substrate while others are able to accommodate a vast array of organic molecules while still differentiating a methyl from an ethyl group. In humans, some cytochrome P450s are involved in the critical metabolism of drug metabolism and pollutant detoxification. Others are involved in steroid and eicosanoid biosynthesis. In plants, most of the secondary metabolism pathways include one or several cytochrome P450s. Eukaryotic P450s, being membrane-bound, are difficult to crystallize. Most of them lack a known experimental 3D structure. The very recent advent of the deep-learning artificial intelligence AlphaFold2 and AlphaFold3 has opened fast access to the 3D structures of all membrane-bound P50s and of their complexes with associated redox proteins and effectors. Original manuscripts and reviews dealing with any aspect of cytochrome P450s and related aspects are welcome.
Dr. Philippe Urban
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cytochrome P450 (P450)
- cytochrome b5
- NADPH-P450 oxidoreductase (CPR)
- heme
- flavin
- P450 structure
- P450 catalytic activities
- prokaryotic P450
- eukaryotic P450
- viral P450
- drug metabolism
- detoxification
- plant secondary metabolisms
- membrane protein–protein complex
- AlphaFold
- AlphaFold2
- regulation of P450 transcription
- catalytic cavities
- substrate access channels
- prediction of protein–protein complexes
- P450 interaction on P450–CPR complexes
- tripartite P450–CPR–cytochrome b5 complex
