Therapeutic Targets of Neuroprotection and Neurorestauration in Ischemic Stroke

Dear Colleagues,

Stroke is one of the leading causes of death and disability worldwide. The current treatment strategies for ischemic stroke primarily focus on reducing the size of ischemic damage and rescuing dying cells early after occurrence. The pathophysiology of strokes is complex and it involves excitotoxicity mechanisms, inflammatory pathways, oxidative damage, ionic imbalances, apoptosis, angiogenesis, neuroprotection, and neurorestoration.

Multiple factors such as excitotoxicity, inflammation, angiogenesis, and neurogenesis are the main pathological processes that underlie acute and chronic ischemic brain injury. Furthermore, their intimate interactions mediate blood–brain barrier permeability and increase neurovascular unit structural damage, as well as hemorrhagic transformation during an ischemic stroke.

Neuroprotective and neurorestorative therapy represent two major drug intervention strategies for ischemic strokes.

Time is crucial in managing strokes to reduce the rapidly progressing insult of the ischemic penumbra and the serious neurologic deficits that might follow it. Strokes are mainly either hemorrhagic or ischemic, with ischemic being the most common of all types of strokes. Thrombolytic therapy with recombinant tissue plasminogen activators and endovascular thrombectomy are the main types of management of acute ischemic strokes. Neuroprotective agents are important to investigate, as they may reduce mortality, lessen disability, and improve quality of life after AIS. In our review, we will discuss the main types of management and the different modalities of neuroprotection, their mechanisms of action, and evidence of their effectiveness after ischemic strokes.

The aims and scope of this Special Issue are to enhance our knowledge concerning the therapeutic targets of neuroprotection and neurorestauration in ischemic stroke.

Prof. Dr. Arieh S Solomon
Guest Editor

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• neuroprotection
• neurorestoration
• Ischemic Stroke
• stroke therapy
• stroke etiology
• risk factors