Recent Advances and Future Directions for the Diagnosis and Treatment of Progressive Supranuclear Palsy

Dear Colleagues,

Progressive supranuclear palsy is a primary tauopathy in which abnormal phosphorylated Tau with 4R predominance accumulates. It often presents symptoms similar to those of Parkinson’s disease, such as akinesia and postural instability, and differential diagnosis is often difficult, particularly in its early stages. Early and accurate diagnosis and the establishment of effective disease-modifying therapy are necessary to overcome this disorder.

The aim of this Special Issue is to share the latest evidence and future directions in this field of research, focusing on the diagnosis and treatment of PSP. Firstly, regarding diagnosis, we welcome studies addressing various imaging modalities (especially MRI and PET (Tau, inflammation), fluid biomarkers (t-Tau, p-Tau, MTBR-Tau) and seeding activity using RT-QuiC. Next, we welcome research on pharmacological treatments such as genetic therapy, microtubule stabilization, post-translational modifications and immunotherapy. Papers that address non-pharmacological treatments (rehabilitation, care) are also welcome.

This Special Issue will allow physicians, basic researchers, and those involved in drug development to comprehend recent advances in the field and develop the domain further.

• Diagnosis
• Imaging
• MRI
• PET(Tau, inflamation) 
• Fluid biomarker
• t-Tau, p-Tau, MTBR-Tau
• RT-QuiC 

• Treatment
• Pharmacological treatment
• Genetic therapy
• Microtubule stabilizing
• Post translational modifications
• Immunotherapy

• Non-Pharmachological treatment
• Rehabilitation
• Care

Dr. Ikuko Aiba
Dr. Günter U. Höglinger
Dr. Adam Boxer
Guest Editors

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• MRI
• PET
• biomarker
• Tau
• RT-QuiC
• treatment
• disease-modifying therapy
• immunotherapy
• rehabilitation
• care