Special Issue "Endocannabinoid System and Neurodegenerative Disorders"

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".

Deadline for manuscript submissions: 1 April 2022.

Special Issue Editors

Dr. Marco Colizzi
E-Mail Website1 Website2
Guest Editor
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Interests: psychosis; neuropsychopharmacology; brain imaging; cannabinoids; cognitive neuroscience
Special Issues, Collections and Topics in MDPI journals
Dr. Gennaro Pagano
E-Mail Website
Guest Editor
F. Hoffmann-La Roche AG, Basel, Switzerland
Interests: neuropsychopharmacology; Cognitive Dysfunction

Special Issue Information

Dear Colleagues, 

Over the years, there have been remarkable advancements in our understanding of the neurobiological underpinnings of neurodegeneration. However, despite tremendous progresses in the field, the translation of promising disease models and treatment options to the clinic of neurodegenerative disorders has thus far been modest, calling into question the difficulty of modeling normal and pathological processes occurring with aging. There is still a paucity of available treatments for neurodegeneration and most of them provide only symptomatic relief, far from being curative or disease-modifying drugs.

The last decades have also witnessed increasing knowledge of the endocannabinoid system and its potential implications for health and disease. Compounds exerting agonist or antagonist properties at cannabinoid receptors have shown a wide range of actions, from accelerating pathological processes to being therapeutic and possibly halting disease progression. Thus, it is plausible that both exogenous cannabinoids (e.g., plant-derived cannabinoids Δ9-tetrahydrocannabinol, Δ9-THC, and cannabidiol, CBD) and their endogenous counterparts (e.g., endocannabinoids anandamide and 2-arachidonoylglycerol, 2-AG) as well as naturally occurring N-acylethanolamines may directly or indirectly interact with the endocannabinoid system, modulating human brain function and behavior in different ways, with different risk–benefit profiles for neuropsychiatric aging-associated disorders.

Under this perspective, it is imperative to study the effects that targeting the endocannabinoid system may have for the pathogenesis of common neurodegenerative processes, including, but not limited to, oxidative stress, neuroinflammation, and glutamatergic imbalance. Preclinical and clinical studies investigating the endocannabinoid system in the etiology, brain processes and multifaceted behavioral phenotypes associated with neurodegenerative disorders are solicited for this Special Issue. Reviews providing an analytical perspective of the existing literature on the “Endocannabinoid System and Neurodegenerative Disorders” are also welcome.

Dr. Marco Colizzi
Dr. Gennaro Pagano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neurodegeneration
  • neuropsychopharmacology
  • brain imaging
  • Parkinson
  • PET

Published Papers

This special issue is now open for submission.
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