Diagnosis, Molecular Classification, and Treatment of T-Cell Lymphomas

Dear Colleagues,

T-cell lymphomas are a heterogeneous group of entities that still pose a diagnostic, classification and therapeutic challenge. Recent advances in molecular biology have made it possible to classify these entities better. However, this has not yet translated into significant therapy changes and even less in the adverse prognosis that characterizes most subtypes. Only CD30+, ALK+ and T-follicular helper lymphomas seem to have new therapies that could improve their prognosis.

The main objective of this edition is to comprehensively review the biology of the different entities that comprise T-lymphomas and how the diagnosis is reached for their classification. Likewise, the therapies in use with their degree of recommendation and the new molecules under study with potential applications will be discussed.

This Special Issue is crucial to understand advances in the various pathogenic pathways of T-cell lymphoma (epigenetic aberrations, TCR, SYK, JAK, PI3K, EZH1/2, HDAC, BCL2) to design and guide the management of very complex patients.

Dr. Silvana Novelli
Guest Editor

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• T-cell lymphomas
• hematopoietic stem cell transplant
• cellular therapy
• monoclonal antibodies
• bispecific T-cell engager
• hypomethylating agents
• TCR
• SYK
• JAK
• PI3K
• EZH1/2
• HDAC
• BCL2