Transcription Factors in Breast Cancer

Dear Colleagues,

Breast cancers are generally identified and treated based on ER, PR, and Her2 expression status. These proteins are often drivers of the cancer. ER and PR modulate a transcription program promoting tumor proliferation, whereas Her2 activates a signaling cascade, leading to the activation of a variety of transcription factors. Moreover, triple-negative breast cancers lack these drivers of breast cancer and often have an activation of different transcription factors that regulate many genes promoting proliferation, metastasis and resistance to chemotherapy. Understanding which transcription factors are active in breast cancers, TNBC or others, may provide new avenues for treating breast cancer. Therefore, this Special Issue will focus on various transcription factors that are activated in breast cancer, looking at the signaling pathways associated with the transcription factors, understanding the gene signatures regulated by these transcription factors, or identifying molecules to target these transcription factors.

Dr. Sarah Walker
Guest Editor

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• breast cancer
• transcription factors
• signaling pathways
• hormone receptors
• targeted therapy