Metabolomics and Proteomics in Bioprocessing

Dear Colleagues,

Bioprocessing demands constant and sensitive monitoring. Moreover, the optimization of both the process and the product is the final target. In an era in which omics analyses are almost part of the research routine, they are constantly becoming more high-throughput and robust. Omics datasets provide deep and holistic insights into the cell regulation activities and growth behavior of the cultures. Particularly, proteomics and metabolomics analyses, focusing on dynamic processes of the cellular function, can offer valuable information about the cell culture state. This state can be informative and predictive about the final product. In this Issue, we will provide latest updates and opinions about how proteomics and metabolomics datasets have contributed and will contribute to fulfilling the aims of metabolic engineering, cell culture engineering (biologics), and stem cell and cell therapy bioprocessing. We will also discuss automation with the use of omics analysis and how machine learning approaches will benefit from proteomics and metabolomics data.

Dr. Spyros I. Vernardis
Dr. Maria Klapa
Guest Editors

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