Debris Clearance by Microglia in Health and Disease
A special issue of Neuroglia (ISSN 2571-6980).
Deadline for manuscript submissions: 31 August 2024 | Viewed by 82
Special Issue Editors
Interests: microglia; neurodegeneration; epigenetics; metabolism; cellular stress response pathways
2. Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain
Interests: astrocytes; microglia; neuroinflammation; phagocytosis; autophagy
Special Issue Information
Dear Colleagues,
Microglia are the brain’s primary phagocytes. As such, a core function of microglia in maintaining tissue homeostasis, regulating inflammation and promoting regeneration involves the phagocytic clearance of apoptotic cells, cellular debris, myelin and protein aggregates. This clearance function is amplified in development, brain injury, aging and neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, frontotemporal dementia and Pick’s disease. Furthermore, it can protect the brain from debris accumulation. The clearance potential of microglia declines with aging, and an insufficient clearance of microglia is thought to contribute to the pathology of several neurodegenerative diseases, most notably Alzheimer’s disease. Microglial phagocytic clearance can also go awry during disease and aberrantly remove healthy neurons and synapses, exacerbating neurodegeneration. Therefore, elucidating the molecular mechanisms underlying microglial phagocytosis is critical in furthering our understanding of brain development, aging and diseases.
The purpose of this Special Issue is to receive original research articles and reviews that focus on recognition and regulatory mechanisms, as well as the functional outcomes of microglial phagocytic clearance and downstream epigenetic, transcriptional and metabolic events that result from microglial clearance activity.
Dr. Pinar Ayata
Dr. Maria-Angeles Arevalo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neuroglia is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- microglia
- phagocytosis
- neurodegeneration
- neuroinflammation
- debris clearance
- regeneration
