Novel Advances in Cellular and Molecular Mechanisms Governing Liver Pathophysiology

Dear Colleagues,

Liver functions are finely tuned by environmental stimuli, which translate into adaptative cellular behaviors partly through modulation of their transcriptome. While these mechanisms have historically been studied in detail in hepatocytes, current efforts also aim to better define how the activities of additional liver cell types are controlled. Indeed, cells of the non-parenchymal fraction and their inter-cellular cross-talks with hepatocytes are increasingly being defined as central components in healthy and injured livers. In this context, liver physiological activities, regenerative capacity, and alterations in acute or chronic conditions are driven by coordinated molecular changes in the different liver cell types. These mechanisms are now investigated at (multi-)omics levels, allowing us to obtain novel insights into the molecular control of liver cells’ activities. A previous Special Issue, entitled “Cellular and Molecular Mechanisms Governing Liver Pathophysiology”, was very successful, comprising 10 papers and reviews concerning various aspects of liver pathophysiology. However, mechanisms related to liver pathophysiology are complicated and dynamic, making them difficult to cover in one Special Issue. Therefore, we aim to work towards creating an additional Special Issue on this topic.

The purpose of this Special Issue is to highlight recent findings that shed light on how the functions of hepatocytes and non-parenchymal cells are controlled at the molecular level to trigger adaptative or maladaptive responses in liver pathophysiology. We welcome the submission of both original research articles and reviews. All scientists working in these fields are cordially invited to submit their manuscripts.

All papers will be published on an ongoing basis with full open access. We look forward to receiving your interesting contributions.

You may choose our Joint Special Issue in Cells.   

Dr. Jérôme Eeckhoute
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathophysiology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• functional genomics
• transcriptional regulation
• cell identity
• cell plasticity
• single-cell omics
• cellular dialogues
• hepatocytes
• non-parenchymal cells
• liver pathophysiology