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Article

Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21) Leukemia

by 1,2,3,*, 1, 1 and 2,*
1
School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China
2
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
3
Laboratory of Chinese Herbal Pharmacology, Oncology Center, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 24 February 2016 / Revised: 22 April 2016 / Accepted: 25 April 2016 / Published: 30 April 2016
(This article belongs to the Section Natural Products Chemistry)
Resistance to chemotherapy is a major challenge to improving overall survival in Acute Myeloid Leukemia (AML). Therefore, the development of innovative therapies and the identification of more novel agents for AML are urgently needed. Celastrol, a compound extracted from the Chinese herb Tripterygium wilfordii Hook, exerts anticancer activity. We investigated the effect of celastrol in the t(8;21) AML cell lines Kasumi-1 and SKNO-1. We demonstrated that inhibition of cell proliferation activated caspases and disrupted mitochondrial function. In addition, we found that celastrol downregulated the AML1-ETO fusion protein, therefore downregulating C-KIT kinases and inhibiting AKT, STAT3 and Erk1/2. These findings provide clear evidence that celastrol might provide clinical benefits to patients with t(8;21) leukemia. View Full-Text
Keywords: celastrol; t(8;21) leukemia; apoptosis; mitochondrial dysfunction; C-KIT celastrol; t(8;21) leukemia; apoptosis; mitochondrial dysfunction; C-KIT
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MDPI and ACS Style

Yu, X.; Ruan, X.; Zhang, J.; Zhao, Q. Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21) Leukemia. Molecules 2016, 21, 574. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules21050574

AMA Style

Yu X, Ruan X, Zhang J, Zhao Q. Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21) Leukemia. Molecules. 2016; 21(5):574. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules21050574

Chicago/Turabian Style

Yu, Xianjun, Xuzhi Ruan, Jingxuan Zhang, and Qun Zhao. 2016. "Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21) Leukemia" Molecules 21, no. 5: 574. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules21050574

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