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Review

Phage Display Technology in Biomarker Identification with Emphasis on Non-Cancerous Diseases

by
Mohammad Sadraeian
1,
Reza Maleki
2,
Mahta Moraghebi
2 and
Abasalt Bahrami
3,*,†
1
Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia
2
Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia
3
Department of Chemistry and Biochemistry, Bioengineering, and Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
Current address: Department of Neurology, Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, CA 90095, USA.
Submission received: 12 March 2024 / Revised: 17 April 2024 / Accepted: 29 April 2024 / Published: 25 June 2024

Abstract

In recent years, phage display technology has become vital in clinical research. It helps create antibodies that can specifically bind to complex antigens, which is crucial for identifying biomarkers and improving diagnostics and treatments. However, existing reviews often overlook its importance in areas outside cancer research. This review aims to fill that gap by explaining the basics of phage display and its applications in detecting and treating various non-cancerous diseases. We focus especially on its role in degenerative diseases, inflammatory and autoimmune diseases, and chronic non-communicable diseases, showing how it is changing the way we diagnose and treat illnesses. By highlighting important discoveries and future possibilities, we hope to emphasize the significance of phage display in modern healthcare.
Keywords: phage display; biopanning; diagnosis; therapeutic applications phage display; biopanning; diagnosis; therapeutic applications

Share and Cite

MDPI and ACS Style

Sadraeian, M.; Maleki, R.; Moraghebi, M.; Bahrami, A. Phage Display Technology in Biomarker Identification with Emphasis on Non-Cancerous Diseases. Molecules 2024, 29, 3002. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules29133002

AMA Style

Sadraeian M, Maleki R, Moraghebi M, Bahrami A. Phage Display Technology in Biomarker Identification with Emphasis on Non-Cancerous Diseases. Molecules. 2024; 29(13):3002. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules29133002

Chicago/Turabian Style

Sadraeian, Mohammad, Reza Maleki, Mahta Moraghebi, and Abasalt Bahrami. 2024. "Phage Display Technology in Biomarker Identification with Emphasis on Non-Cancerous Diseases" Molecules 29, no. 13: 3002. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules29133002

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