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Volume 29
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

The Chromenopyridine Scaffold: A Privileged Platform in Drug Design

by
Fábio Pedroso de Lima
1,2,
Marta Costa
3,4,
Ana Sousa
1,3,4 and
Maria Fernanda Proença
1,*
1
Chemistry Centre, School of Sciences, University of Minho, Gualtar Campus, 4715-303 Braga, Portugal
2
Centre for Textile Science and Technology (2C2T), University of Minho, Azurém Campus, 4800-058 Guimarães, Portugal
3
Life and Health Sciences Research Institute (ICVS), University of Minho, Gualtar Campus, 4710-057 Braga, Portugal
4
ICVS/3B’s—PT Government Associate Laboratory, 4710-057 Braga/Guimarães, Portugal
*
Author to whom correspondence should be addressed.
Molecules 2024, 29(13), 3004; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules29133004
Submission received: 23 April 2024 / Revised: 7 June 2024 / Accepted: 19 June 2024 / Published: 25 June 2024
(This article belongs to the Special Issue Heterocyclic Compounds for Drug Design and Drug Discovery)
Versions Notes

Abstract

The chromenopyridine scaffold represents an important class of heterocyclic compounds exhibiting a broad spectrum of biological properties. This review describes novel and efficient procedures for the synthesis of this scaffold. Herein, several methods were detailed and grouped according to their starting material (e.g., salicylaldehydes, chromones, chromanones and coumarins) and respective biological activity, when reported. This review highlights the potential of the reported synthetic strategies for preparing chromenopyridine derivatives with promising biological activity, paving the way for further developments in drug discovery.
Keywords: pyridine; chromene; chromenopyridine; synthesis; biological activity pyridine; chromene; chromenopyridine; synthesis; biological activity

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MDPI and ACS Style

Pedroso de Lima, F.; Costa, M.; Sousa, A.; Proença, M.F. The Chromenopyridine Scaffold: A Privileged Platform in Drug Design. Molecules 2024, 29, 3004. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules29133004

AMA Style

Pedroso de Lima F, Costa M, Sousa A, Proença MF. The Chromenopyridine Scaffold: A Privileged Platform in Drug Design. Molecules. 2024; 29(13):3004. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules29133004

Chicago/Turabian Style

Pedroso de Lima, Fábio, Marta Costa, Ana Sousa, and Maria Fernanda Proença. 2024. "The Chromenopyridine Scaffold: A Privileged Platform in Drug Design" Molecules 29, no. 13: 3004. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules29133004

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