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Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease

Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Turin, Italy
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Int. J. Mol. Sci. 2013, 14(2), 2617-2636; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms14022617
Received: 13 November 2012 / Revised: 11 January 2013 / Accepted: 12 January 2013 / Published: 28 January 2013
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases)
Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly. View Full-Text
Keywords: embryonic stem cells; genotoxic stress; DNA repair; aging; tumor embryonic stem cells; genotoxic stress; DNA repair; aging; tumor
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MDPI and ACS Style

Giachino, C.; Orlando, L.; Turinetto, V. Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease. Int. J. Mol. Sci. 2013, 14, 2617-2636. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms14022617

AMA Style

Giachino C, Orlando L, Turinetto V. Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease. International Journal of Molecular Sciences. 2013; 14(2):2617-2636. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms14022617

Chicago/Turabian Style

Giachino, Claudia, Luca Orlando, and Valentina Turinetto. 2013. "Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease" International Journal of Molecular Sciences 14, no. 2: 2617-2636. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms14022617

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