Next Article in Journal
Effect of Lead (Pb) on Inflammatory Processes in the Brain
Next Article in Special Issue
Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis
Previous Article in Journal
Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations
Previous Article in Special Issue
Toll Like Receptor 2, 4, and 9 Signaling Promotes Autoregulative Tumor Cell Growth and VEGF/PDGF Expression in Human Pancreatic Cancer
Review

Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications

Department of Pathology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Srikumar Chellappan and Jaya Padmanabhan
Int. J. Mol. Sci. 2016, 17(12), 2138; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17122138
Received: 15 November 2016 / Revised: 8 December 2016 / Accepted: 14 December 2016 / Published: 19 December 2016
(This article belongs to the Special Issue Pancreatic Disorders)
Pancreatic cancer is one of the most aggressive human cancer types with a five-year survival less than 7%. Emerging evidence revealed that many genetic alterations in pancreatic cancer target epigenetic regulators. Some of these mutations are driver mutations in cancer development. Several most important mechanisms of epigenetic regulations include DNA methylation, histone modifications (methylation, acetylation, and ubiquitination), chromatin remodeling, and non-coding ribonucleic acids (RNAs). These modifications can alter chromatin structure and promoter accessibility, and thus lead to aberrant gene expression. However, exactly how these alterations affect epigenetic reprogramming in pancreatic cancer cells and in different stages of tumor development is still not clear. This mini-review summarizes the current knowledge of epigenetic alterations in pancreatic cancer development and progression, and discusses the clinical applications of epigenetic regulators as diagnostic biomarkers and therapeutic targets in pancreatic cancer. View Full-Text
Keywords: genetic alterations; epigenetic regulators; pancreatic neoplasms; pancreatic cancer; clinical implication genetic alterations; epigenetic regulators; pancreatic neoplasms; pancreatic cancer; clinical implication
Show Figures

Graphical abstract

MDPI and ACS Style

Silverman, B.R.; Shi, J. Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications. Int. J. Mol. Sci. 2016, 17, 2138. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17122138

AMA Style

Silverman BR, Shi J. Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications. International Journal of Molecular Sciences. 2016; 17(12):2138. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17122138

Chicago/Turabian Style

Silverman, Brittany R., and Jiaqi Shi. 2016. "Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications" International Journal of Molecular Sciences 17, no. 12: 2138. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17122138

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop