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Review

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics

by 1, 2, 1,3,* and 1,*
1
Center for Chinese Medical Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2
Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
3
Center for Translational Medicine, and Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Ting-Li (Morgan) Han
Int. J. Mol. Sci. 2016, 17(3), 300; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030300
Received: 11 December 2015 / Revised: 14 February 2016 / Accepted: 17 February 2016 / Published: 15 March 2016
(This article belongs to the Special Issue Metabolomic Technologies in Medicine)
Gut microbiota are intricately involved in the development of obesity-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance. In the current review, we discuss the role of gut microbiota in the development of NAFLD by focusing on the mechanisms of gut microbiota-mediated host energy metabolism, insulin resistance, regulation of bile acids and choline metabolism, as well as gut microbiota-targeted therapy. We also discuss the application of a metabolomic approach to characterize gut microbial metabotypes in NAFLD. View Full-Text
Keywords: gut microbiota; NAFLD; obesity; insulin resistance; bile acids; choline gut microbiota; NAFLD; obesity; insulin resistance; bile acids; choline
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MDPI and ACS Style

He, X.; Ji, G.; Jia, W.; Li, H. Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics. Int. J. Mol. Sci. 2016, 17, 300. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030300

AMA Style

He X, Ji G, Jia W, Li H. Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics. International Journal of Molecular Sciences. 2016; 17(3):300. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030300

Chicago/Turabian Style

He, Xuyun, Guang Ji, Wei Jia, and Houkai Li. 2016. "Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics" International Journal of Molecular Sciences 17, no. 3: 300. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030300

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