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The Question of a Role for Statins in Age-Related Macular Degeneration

1
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
2
Department of Ophthalmology, Federal University of São Paulo, São Paulo 04023-062, Brazil
3
Vision Institute, IPEPO, Department of Ophthalmology, Paulista Medical School, Federal University of São Paulo, São Paulo 04038-032, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(11), 3688; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19113688
Received: 18 October 2018 / Revised: 18 November 2018 / Accepted: 19 November 2018 / Published: 21 November 2018
(This article belongs to the Special Issue Molecular Biology of Age-Related Macular Degeneration (AMD))
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in patients over the age of 65 years in industrialized countries. Epidemiologic studies suggest that high dietary fat intake is a risk factor for the development and progression of both vascular and retinal disease. These, and other associations, suggest a hypothesis linking elevated cholesterol and AMD progression. It follows, therefore, that cholesterol-lowering medications, such as statins, may influence the onset and progression of AMD. However, the findings have been inconclusive as to whether statins play a role in AMD. Due to the significant public health implications of a potential inhibitory effect of statins on the onset and progression of AMD, it is important to continually evaluate emerging findings germane to this question. View Full-Text
Keywords: age-related macular degeneration; atherosclerotic disease; cholesterol; retina; statins age-related macular degeneration; atherosclerotic disease; cholesterol; retina; statins
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MDPI and ACS Style

Roizenblatt, M.; Naranjit, N.; Maia, M.; Gehlbach, P.L. The Question of a Role for Statins in Age-Related Macular Degeneration. Int. J. Mol. Sci. 2018, 19, 3688. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19113688

AMA Style

Roizenblatt M, Naranjit N, Maia M, Gehlbach PL. The Question of a Role for Statins in Age-Related Macular Degeneration. International Journal of Molecular Sciences. 2018; 19(11):3688. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19113688

Chicago/Turabian Style

Roizenblatt, Marina, Nara Naranjit, Mauricio Maia, and Peter L. Gehlbach 2018. "The Question of a Role for Statins in Age-Related Macular Degeneration" International Journal of Molecular Sciences 19, no. 11: 3688. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19113688

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