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Article

Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy

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Department of Clinical Laboratory Science, Kanazawa University School of Medical Sciences, Kanazawa 920-0942, Japan
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Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan
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Hematopoietic Cell Transplantation Center, Aichi Medical University Hospital, Nagakute 480-1195, Japan
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Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan
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Department of Hematology and Oncology, Tokai University School of Medicine, Isehara 259-1193, Japan
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Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo 135-8521, Japan
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Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan
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Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo 104-0045, Japan
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Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, Japan
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Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya 453-8511, Japan
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Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
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Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8641, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(1), 214; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20010214
Received: 8 December 2018 / Revised: 2 January 2019 / Accepted: 4 January 2019 / Published: 8 January 2019
(This article belongs to the Section Molecular Oncology)
Relapse remains a major obstacle to the survival of patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation. A disintegrin-like and metalloprotease with a thrombospondin type 1 motif (ADMATS13), which cleaves von Willebrand factor multimers into less active fragments, is encoded by the ADAMTS13 gene and has a functional single-nucleotide polymorphism (SNP) rs2285489 (C > T). We retrospectively examined whether ADAMTS13 rs2285489 affected the transplant outcomes in a cohort of 281 patients who underwent unrelated human leukocyte antigen (HLA)-matched bone marrow transplantation for hematologic malignancies. The recipient ADAMTS13 C/C genotype, which putatively has low inducibility, was associated with an increased relapse rate (hazard ratio [HR], 3.12; 95% confidence interval [CI], 1.25–7.77; P = 0.015), resulting in a lower disease-free survival rate in the patients with a recipient C/C genotype (HR, 1.64; 95% CI, 1.01–2.67; P = 0.045). Therefore, ADAMTS13 rs2285489 genotyping in transplant recipients may be a useful tool for evaluating pretransplantation risks. View Full-Text
Keywords: ADAMTS13; unrelated donor; bone marrow transplantation; single nucleotide polymorphism ADAMTS13; unrelated donor; bone marrow transplantation; single nucleotide polymorphism
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MDPI and ACS Style

Nomoto, H.; Takami, A.; Espinoza, J.L.; Onizuka, M.; Kashiwase, K.; Morishima, Y.; Fukuda, T.; Kodera, Y.; Doki, N.; Miyamura, K.; Mori, T.; Nakao, S.; Morishita, E. Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy. Int. J. Mol. Sci. 2019, 20, 214. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20010214

AMA Style

Nomoto H, Takami A, Espinoza JL, Onizuka M, Kashiwase K, Morishima Y, Fukuda T, Kodera Y, Doki N, Miyamura K, Mori T, Nakao S, Morishita E. Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy. International Journal of Molecular Sciences. 2019; 20(1):214. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20010214

Chicago/Turabian Style

Nomoto, Haruka, Akiyoshi Takami, J. L. Espinoza, Makoto Onizuka, Koichi Kashiwase, Yasuo Morishima, Takahiro Fukuda, Yoshihisa Kodera, Noriko Doki, Koichi Miyamura, Takehiko Mori, Shinji Nakao, and Eriko Morishita. 2019. "Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy" International Journal of Molecular Sciences 20, no. 1: 214. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20010214

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