Plant DNA Polymerases
Abstract
:1. Introduction
2. Replicative DNA Polymerases, Guardians of the Genome and Epigenome Integrity
3. Division of Labor between Replicative Polymerases at the Replication Fork
4. Subunit Composition of Plant Replicative Polymerases
4.1. DNA Pol ε
4.2. DNA Polymerase α
4.3. Polymerase δ
5. Role of Plant Replicative Pols in Replicative Stress Signaling
6. Putative Roles of Replicative Polymerases in Somatic and Meiotic DNA Repair
7. Role of Plant Replicative Polymerases in the Maintenance of the Epigenetic Information
8. Future Directions for Replicative Polymerase Research
9. Non-Replicative DNA Polymerases, Shared and Unique Functions
10. Role of Non-Replicative Polymerases in TLS
11. Role of Non-Replicative Polymerases in DNA Repair
12. Organellar DNA Polymerases Are Involved both in DNA Replication and Repair
13. Concluding Remarks
Funding
Conflicts of Interest
References
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DNA Pol | Human (Gene/Protein) | S. Cerevisiae/S. Pombe (Gene/Gene) | A. Thaliana |
---|---|---|---|
Pol α/primase | POLA1/p180 | POL1/pol1 | POLA1 (ICU2, AT5G67100) |
POLA2/p70 | POL12/pol12 | POLA2 (AT1G67630) | |
PRIM1/p49 | PRI1/pri1 | PRIM1 (AT1G67320) | |
PRIM2/p58 | PRI2/pri2 | PRIM2 (AT5G41880) | |
Pol δ holoenzyme | POLD1/p125 | POL3/pol3 | POLD1 (AT5G63960) |
POLD2/p50 | POL31/cdc1 | POLD2 (AT2G42120) | |
POLD3/p68 | POL32/cdc27 | POLD3 (AT1G78650) | |
POLD4/p12 | - /cdm1 | POLD4 (AT1G09815) | |
Pol ε holoenzyme | POLE1/p261 POLE2/p59 POLE3/p17 POLE4/p12 | POL2/cdc20 DPB2/dpb2 DPB3/dpb3 DPB4/dpb4 | POL2A (ABO4/ESD7, AT1G08260) DPB2 (AT5G22110) DPB3 (NF-YC13, AT5G43250; NF-YC10, AT1G07980) DPB4 (NF-YB11, AT2G27470) |
Polymerase | Cellular Function | References |
---|---|---|
B-family (Pol α, δ, ε, and ζ in human) | ||
Pol alpha (α) | Deficiency induces HR | [41] |
DSB repair in meiosis | [42] | |
Maintenance of histone marks | [38,41,43] | |
Maintenance of telomeres | [44] | |
Response to abscisic acid (ABA) | [45] | |
Pol delta (δ) | Deficiency induces HR | [40,46] |
DSB repair in meiosis | [47] | |
Maintenance of histone marks | [40,48] | |
Response to DNA-damaging agents | [48] | |
Pol epsilon (ε) | Checkpoint signaling | [49,50] |
DSB repair in meiosis and meiotic checkpoint | [50,51] | |
Deficiency induces HR | [39] | |
Maintenance of histone marks | [39,52,53] | |
Response to abscisic acid (ABA) | [39] | |
Pol zeta (ζ) REV3 (AT1G67500) REV7 (AT1G16590) | TLS (UV-induced lesions) Repair or intra and inter-strand crosslink | [54,55,56,57,58,59] [57] |
X-family (Pol λ, β, μ, and TdT in human) | ||
Pol lambda (λ) | TLS (8-oxo-G) | [32] |
(AT1G10520) | DSB repair | [60,61] |
Pol eta (η) POLH (AT5G44740) | TLS (UV-induced lesions) | [54] |
Y-family (Pol κ, ι, η, and REV1 in human) | ||
Pol kappa (κ) (AT1G49980) | [62] | |
Pol Rev1 (AT5G44750) | TLS (UV-induced damage) | [54,55] |
A-family (Pol θ, γ, and ν in human) | ||
Pol theta (θ) | TLS (required for normal progression of DNA replication) | [63,64] |
POLQ (AT4G32700) | DSB repair through alternative NHEJ | [65] |
Archaeo-eukaryotic primase family PrimPol | ||
PRIMPOL (AT5G52800) | Not functionally characterized yet, putative role in organelle DNA replication | [66] |
Plant organelle polymerases (POPs) | ||
Pol1-like A (Pol γ1, AT3G20540) | Organellar replication and repair, potentially more specifically involved in DNA replication | [67,68,69] |
Pol1-like B (Pol γ2, AT1G50840) | Organellar replication and repair, potentially more specifically involved in DNA repair | [67,68,69] |
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Pedroza-Garcia, J.-A.; De Veylder, L.; Raynaud, C. Plant DNA Polymerases. Int. J. Mol. Sci. 2019, 20, 4814. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20194814
Pedroza-Garcia J-A, De Veylder L, Raynaud C. Plant DNA Polymerases. International Journal of Molecular Sciences. 2019; 20(19):4814. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20194814
Chicago/Turabian StylePedroza-Garcia, Jose-Antonio, Lieven De Veylder, and Cécile Raynaud. 2019. "Plant DNA Polymerases" International Journal of Molecular Sciences 20, no. 19: 4814. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20194814