Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives
Abstract
:1. Introduction
2. Bone Tissue Repair: H2S as a Suitable Biological Cue for Scaffold Functionalization
2.1. H2S Regulates Inflammation in Bone Tissue
2.2. H2S Regulates Migration and Survival of Cells Involved in Bone Repair
2.3. H2S Promotes the Expression of Angiogenic Factors in Bone Tissue
2.4. H2S Stimulates Bone Formation
3. H2S-Releasing Scaffolds for Regenerative Medicine
4. Perspectives for H2S-Loaded Scaffolds for BTE
5. Concluding Remarks
Author Contributions
Funding
Conflicts of Interest
References
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Ref. | Authors | H2S-Donor | In Vitro/In Vivo | Species | Main Findings |
---|---|---|---|---|---|
[14] | Grassi et al. |
| In vivo In vitro | Mice |
|
[15] | Liu et al. |
| In vivo | Mice |
|
[16] | Behera et al. |
| In vivo | Mice |
|
[75] | Gambari et al. | GYY4137 loaded in a SF scaffold | In vitro | Human |
|
[81] | Zhai et al. | NaHS | In vitro | Murine cell line |
|
[82] | Lv et al. | GYY4137 | In vitro | Murine cell line |
|
[83] | Mo et al. | GYY4137 | In vivo | Mice |
|
[86] | Lee et al. | NaHS | In vitro | Human Mice |
|
[88] | Jiang et al. | NaHS | In vitro | Human |
|
[89] | Pu et al. | NaHS | In vivo | Mice |
|
[90] | Xu et al. | GYY4137 | In vivo | Rat |
|
[91] | Behera et al. | NaHS | In vivo In vitro | Mice |
|
[93] | Yang et al. | NaHS | In vivo | Rats |
|
[94] | Jiang et al. | GYY4137 | In vivo | Rabbits |
|
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Gambari, L.; Grigolo, B.; Grassi, F. Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives. Int. J. Mol. Sci. 2019, 20, 5231. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20205231
Gambari L, Grigolo B, Grassi F. Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives. International Journal of Molecular Sciences. 2019; 20(20):5231. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20205231
Chicago/Turabian StyleGambari, Laura, Brunella Grigolo, and Francesco Grassi. 2019. "Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives" International Journal of Molecular Sciences 20, no. 20: 5231. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20205231