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Anti-Aging Effects of GDF11 on Skin

Equipe d’Accueil (EA 7460): Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Université de Bourgogne—Franche Comté, Faculté des Sciences de Santé, 7 Bd Jeanne d’Arc, 21000 Dijon, France
Centre interface Applications Médicales CIAM, Université Mohammed VI Polytechnique, Ben-Guerir 43 150, Morocco
CHU Cardiology Unit Dijon, 21000 Dijon, France
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2598;
Received: 18 March 2020 / Revised: 2 April 2020 / Accepted: 7 April 2020 / Published: 9 April 2020
(This article belongs to the Special Issue Skin Epidermis and Barrier Function)
Human skin is composed of three layers: the epidermis, the dermis, and the hypodermis. The epidermis has four major cell layers made up of keratinocytes in varying stages of progressive differentiation. Skin aging is a multi-factorial process that affects every phase of its biology and function. The expression profiles of inflammation-related genes analyzed in resident immune cells demonstrated that these cells have a strong ability to regenerate adult skin stem cells and to produce endogenous substances such as growth differentiation factor 11 (GDF11). GDF11 appears to be the key to progenitor proliferation and/or differentiation. The preservation of youthful phenotypes has been tied to the presence of GDF11 in different human tissues, and, in the skin, this factor inhibits inflammatory responses. The protective role of GDF11 depends on a multi-factorial process implicating various types of skin cells such as keratinocytes, fibroblasts and inflammatory cells. GDF11 should be further studied for the purpose of developing novel therapies for the treatment of skin diseases. View Full-Text
Keywords: skin aging; regeneration; growth factors; disease skin aging; regeneration; growth factors; disease
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MDPI and ACS Style

Rochette, L.; Mazini, L.; Meloux, A.; Zeller, M.; Cottin, Y.; Vergely, C.; Malka, G. Anti-Aging Effects of GDF11 on Skin. Int. J. Mol. Sci. 2020, 21, 2598.

AMA Style

Rochette L, Mazini L, Meloux A, Zeller M, Cottin Y, Vergely C, Malka G. Anti-Aging Effects of GDF11 on Skin. International Journal of Molecular Sciences. 2020; 21(7):2598.

Chicago/Turabian Style

Rochette, Luc; Mazini, Loubna; Meloux, Alexandre; Zeller, Marianne; Cottin, Yves; Vergely, Catherine; Malka, Gabriel. 2020. "Anti-Aging Effects of GDF11 on Skin" Int. J. Mol. Sci. 21, no. 7: 2598.

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