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Sarcopenia: Etiology, Nutritional Approaches, and miRNAs

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
Galascreen Laboratories, University of Calabria, 87036 Rende, Italy
Research Division, Dynamical Business & Science Society, DBSS International SAS, Bogotá 110311, Colombia
Faculty of Medicine, University of Salvador, Buenos Aires 1020, Argentina
Research Group in Physical Activity, Sports and Health Sciences (GICAFS), Universidad de Córdoba, Montería 230002, Colombia
Faculty of Sport Sciences, EADE-University of Wales Trinity Saint David, 29018 Málaga, Spain
Grupo de Investigación Programa de Medicina (GINUMED), Corporación Universitaria Rafael Núñez, Cartagena 130001, Colombia
Health and Sport Sciences Research Group, School of Health and Sport Sciences, Fundación Universitaria del Área Andina, Bogotá 111221, Colombia
Sport Genomics Research Group, Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, 48940 Leioa, Spain
kDNA Genomics®, Joxe Mari Korta Research Center, University of the Basque Country UPV/EHU, 20018 Donostia-San Sebastián, Spain
Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Texas A&M University, College Station, TX 77843, USA
Research Group in Biochemistry and Molecular Biology, Universidad Distrital Francisco José de Caldas, Bogotá 110311, Colombia
Authors to whom correspondence should be addressed.
Academic Editor: Jin-Ho Koh
Int. J. Mol. Sci. 2021, 22(18), 9724;
Received: 19 August 2021 / Revised: 3 September 2021 / Accepted: 6 September 2021 / Published: 8 September 2021
(This article belongs to the Special Issue Molecular and Cellular Exercise Physiology in Metabolism)
Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial syndrome, the etiology and underlying mechanisms are not yet delineated. Moreover, research about nutritional interventions to prevent the development of sarcopenia is mainly focused on the amount and quality of protein intake. The impact of several nutrition strategies that consider timing of food intake, anti-inflammatory nutrients, metabolic control, and the role of mitochondrial function on the progression of sarcopenia is not fully understood. This narrative review summarizes the metabolic background of this phenomenon and proposes an integral nutritional approach (including dietary supplements such as creatine monohydrate) to target potential molecular pathways that may affect reduce or ameliorate the adverse effects of sarcopenia. Lastly, miRNAs, in particular those produced by skeletal muscle (MyomiR), might represent a valid tool to evaluate sarcopenia progression as a potential rapid and early biomarker for diagnosis and characterization. View Full-Text
Keywords: mitochondria; aging; protein; muscle; nutritional supplements; MyomiR mitochondria; aging; protein; muscle; nutritional supplements; MyomiR
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MDPI and ACS Style

Cannataro, R.; Carbone, L.; Petro, J.L.; Cione, E.; Vargas, S.; Angulo, H.; Forero, D.A.; Odriozola-Martínez, A.; Kreider, R.B.; Bonilla, D.A. Sarcopenia: Etiology, Nutritional Approaches, and miRNAs. Int. J. Mol. Sci. 2021, 22, 9724.

AMA Style

Cannataro R, Carbone L, Petro JL, Cione E, Vargas S, Angulo H, Forero DA, Odriozola-Martínez A, Kreider RB, Bonilla DA. Sarcopenia: Etiology, Nutritional Approaches, and miRNAs. International Journal of Molecular Sciences. 2021; 22(18):9724.

Chicago/Turabian Style

Cannataro, Roberto, Leandro Carbone, Jorge L. Petro, Erika Cione, Salvador Vargas, Heidy Angulo, Diego A. Forero, Adrián Odriozola-Martínez, Richard B. Kreider, and Diego A. Bonilla 2021. "Sarcopenia: Etiology, Nutritional Approaches, and miRNAs" International Journal of Molecular Sciences 22, no. 18: 9724.

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