Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation
Abstract
:1. Introduction
2. Regulation of Chromatin Organization by Phase Separation
2.1. Linker DNA Length and DNA Sequence
2.2. Chromatin-Binding Proteins
2.3. Level of Mg2+ and ATP
2.4. RNA and RNA Binding Protein
2.5. Protein Post-Translation Modifications
3. Phase Separation in DNA Repair and Transcriptional Regulation
3.1. Phase Separation in DNA Repair
3.2. Phase Separation in Transcriptional Regulation
4. Phase Separation in Mitotic Cell Cycle
4.1. Phase Separation in Regulating Centriole Biogenesis
4.2. Phase Separation in Chromosome Segregation
5. Phase Separation in Meiotic Cell Cycle
5.1. Homologous Chromosome Pairing
5.2. Synaptonemal Complex Organization
5.3. Formation of Programmed DNA DSBs
5.4. Spindle Assembly and Chromosome Segregation
6. Conclusions and Prospects
Author Contributions
Funding
Conflicts of Interest
References
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Li, J.; Gao, J.; Wang, R. Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation. Int. J. Mol. Sci. 2021, 22, 12271. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222212271
Li J, Gao J, Wang R. Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation. International Journal of Molecular Sciences. 2021; 22(22):12271. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222212271
Chicago/Turabian StyleLi, Jiaxiang, Jinmin Gao, and Ruoxi Wang. 2021. "Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation" International Journal of Molecular Sciences 22, no. 22: 12271. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222212271