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Article

Intense Pulsed Light Attenuates UV-Induced Hyperimmune Response and Pigmentation in Human Skin Cells

R&D Unit, Amorepacific Corporation, Yongin 17074, Korea
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Author to whom correspondence should be addressed.
Academic Editor: Vladimir Chubanov
Int. J. Mol. Sci. 2021, 22(6), 3173; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063173
Received: 24 February 2021 / Revised: 14 March 2021 / Accepted: 18 March 2021 / Published: 20 March 2021
(This article belongs to the Special Issue Molecular Research of Aging Stress Response)
The skin of an organism is affected by various environmental factors and fights against aging stress via mechanical and biochemical responses. Photoaging induced by ultraviolet B (UVB) irradiation is common and is the most vital factor in the senescence phenotype of skin, and so, suppression of UVB stress-induced damage is critical. To lessen the UVB-induced hyperimmune response and hyperpigmentation, we investigated the ameliorative effects of intense pulsed light (IPL) treatment on the photoaged phenotype of skin cells. Normal human epidermal keratinocytes and human epidermal melanocytes were exposed to 20 mJ/cm2 of UVB. After UVB irradiation, the cells were treated with green (525–530 nm) and yellow (585–592 nm) IPL at various time points prior to the harvest step. Subsequently, various signs of excessive immune response, including expression of proinflammatory and melanogenic genes and proteins, cellular oxidative stress level, and antioxidative enzyme activity, were examined. We found that IPL treatment reduced excessive cutaneous immune reactions by suppressing UVB-induced proinflammatory cytokine expression. IPL treatment prevented hyperpigmentation, and combined treatment with green and yellow IPL synergistically attenuated both processes. IPL treatment may exert protective effects against UVB injury in skin cells by attenuating inflammatory cytokine and melanogenic gene overexpression, possibly by reducing intracellular oxidative stress. IPL treatment also preserves antioxidative enzyme activity under UVB irradiation. This study suggests that IPL treatment is a useful strategy against photoaging, and provides evidence supporting clinical approaches with non-invasive light therapy. View Full-Text
Keywords: intense pulsed light; inflammation; melanogenesis; oxidative stress; antioxidative enzyme activity; photoaging intense pulsed light; inflammation; melanogenesis; oxidative stress; antioxidative enzyme activity; photoaging
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MDPI and ACS Style

Kim, J.; Lee, J.; Choi, H. Intense Pulsed Light Attenuates UV-Induced Hyperimmune Response and Pigmentation in Human Skin Cells. Int. J. Mol. Sci. 2021, 22, 3173. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063173

AMA Style

Kim J, Lee J, Choi H. Intense Pulsed Light Attenuates UV-Induced Hyperimmune Response and Pigmentation in Human Skin Cells. International Journal of Molecular Sciences. 2021; 22(6):3173. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063173

Chicago/Turabian Style

Kim, Juewon, Jeongin Lee, and Hyunjung Choi. 2021. "Intense Pulsed Light Attenuates UV-Induced Hyperimmune Response and Pigmentation in Human Skin Cells" International Journal of Molecular Sciences 22, no. 6: 3173. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063173

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