A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View
Abstract
:1. Introduction
2. Methods
- Female infertility AND high-fat diet*;
- High fat diet AND folliculogenesis;
- High fat diet* AND-1miRNA AND ovarian follicle AND high-fat diet;
- Epigenetic OR methylation OR miRNA OR gene expression AND oocyte AND high-fat diet;
- Oxidative stress OR inflammation AND oocyte AND high-fat diet.
3. Results and Discussion
3.1. Impact of High-Fat Diet on Gene Expression of Folliculogenesis
3.1.1. Impact of HFD on Inflammation Pathways in Folliculogenesis
3.1.2. Impact of HFD on reactive oxygen species (ROS) Production and Oxidative Stress in Mammal Follicles
3.2. Effects of HFD on Gene Expression of Oogenesis
Inflammation and Oxidative Stress Pathways in Oogenesis
4. HFD-Derived Epigenetic Effects
4.1. Epigenetics Mechanisms
4.1.1. HFD Modifications to Gene Promoter Methylation
4.1.2. HFD Modifications to microRNAs’ Expression
4.1.3. HFD Modifications on Histone Modifications
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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References | Species | Main Findings |
---|---|---|
[27] | Mice | Upregulation of sets of genes involved in cellular trafficking and impairment in cytoskeleton organization Alterated gene expression related to inflammatory responses, cell morphogenesis and decreased metabolism |
[28] | Mice | Higher Cart gene expression contributes to lower estradiol synthesis, fewer ovulated oocytes and possible subfertility |
[29] | Mice | Edn2 down-, Ece1 up- gene expression and ET2 protein dysregulation influence the number of ovulated oocytes and overall ovulatory mechanism |
[30] | Mice | Inhbb, Stmn1, and Hsd3b1 higher levels modulate metabolic homeostasis and steroidogenesis in ovarian follicles; Marcks and Prkar2b are potential indicators of folliculogenesis abnormalities |
[31] | Mice | Alteration of steroidogenic genes (Star and Cyp11a1) and E2 receptors (Erα and Erβ) |
References | Species | Main Findings |
---|---|---|
[21] | Mice | Higher levels of proinflammatory cytokines, increased infiltration of ovarian macrophages |
[32] | Mice | Greater penetration of immune cells and higher gene expression inflammatory genes |
[33] | Rat | High levels TNF-α, IL-6 and IL-8 and Egr-1 gene |
[34] | Human | High levels IL-6, IL-8, TNFα and IL-10 |
[35] | Human | FGF-12 and PPM1L over-regulation, activation of inflammatory pathways |
References | Species | Main Findings |
---|---|---|
[10] | Human | Factors related to individual’s lifestyle—smoking |
[21] | Mice | Abnormal inflammatory responses, inflammatory and oxidative stress markers |
[22] | Human | Higher oxidative stress in follicular fluid |
[37] | Pig | Oxidative stress compromises follicular and ovarian development |
[38] | Rat | Significant follicular development damage |
[32] | Mice | Altered ovarian function and female reproductive potential |
[39] | Mice | Activation of glutathione system and Cat gene inducing antioxidant response; Sod2 downregulation correlated to decreased capacity of eliminating ROS |
References | Species | Main Findings |
---|---|---|
[40] | Mice | Higher expression of Gdf9, negative effects on development beyond the zygote stage Raly upregulation affects negatively the development at the 2-cell stage and/or blastocyst |
[41] | Mice | Bmp15 upregulation in GV and MII oocytes; developmental failure-related mechanisms |
[42] | Mice | NAMPT reduction-induced NAD+ insufficiency; compromised quality of oocytes |
[43] | Cow | COC’s ATF4–HSPA5 significantly increased negative impact on protein-folding pathways, oocyte maturation, metabolic dysfunction and embryonic development |
[44] | Mice | COC’s Atf4–Hspa5 significantly increased |
References | Species | Main Findings |
---|---|---|
[45] | Human | GAS7 and TNXIP downregulation; Higher expression of CXCL2, CXCL3, IL-34 and CCL20; decreased oocyte quality and development |
[46] | Mice | Sirt3 significatly lower may contribute to the penetrance of oxidative stress, as well as metabolic and meiotic alteration |
[36] | Mice | Higher expression of pro-apoptotic genes Bak and Bcl-2; cause-related reduction in oocyte quality |
[48] | Mice | Increase in ROS and toxic lipid peroxides |
[49] | Mice | Tigar downregulation further contribution of oxidative stress development |
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Gonnella, F.; Konstantinidou, F.; Di Berardino, C.; Capacchietti, G.; Peserico, A.; Russo, V.; Barboni, B.; Stuppia, L.; Gatta, V. A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View. Int. J. Mol. Sci. 2022, 23, 8890. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23168890
Gonnella F, Konstantinidou F, Di Berardino C, Capacchietti G, Peserico A, Russo V, Barboni B, Stuppia L, Gatta V. A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View. International Journal of Molecular Sciences. 2022; 23(16):8890. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23168890
Chicago/Turabian StyleGonnella, Francesca, Fani Konstantinidou, Chiara Di Berardino, Giulia Capacchietti, Alessia Peserico, Valentina Russo, Barbara Barboni, Liborio Stuppia, and Valentina Gatta. 2022. "A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View" International Journal of Molecular Sciences 23, no. 16: 8890. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23168890