Unhealthy Diets Induce Distinct and Regional Effects on Intestinal Inflammatory Signalling Pathways and Long-Lasting Metabolic Dysfunction in Rats
Abstract
:1. Introduction
2. Results
2.1. Effects of Energy and Macronutrient Intake on Anthropometric Parameters
2.2. Dietary Composition Effects on Serum Metabolic Parameters
2.3. Effects of Obesogenic Diets on the Small Intestine Morphology
2.4. Distinct Effects of Obesogenic Diets on the Number of Goblet Cells
2.5. Distinct Effects of Obesogenic Diets on Inflammatory Signalling Pathways in the Small Intestine
2.6. Distinct Effects of Obesogenic Diets on Inflammatory Signalling Pathways in the Large Intestine
3. Discussion
4. Material and Methods
4.1. Animals and Experimental Diets
4.2. Tissue Collection
4.3. Histological Analysis and Goblet Cell Staining
4.4. Gene Expression Analysis
4.5. Correlation Analysis with Physiological Traits
4.6. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Nogueira, S.; Barbosa, J.; Faria, J.; Sá, S.I.; Cardoso, A.; Soares, R.; Fonseca, B.M.; Leal, S. Unhealthy Diets Induce Distinct and Regional Effects on Intestinal Inflammatory Signalling Pathways and Long-Lasting Metabolic Dysfunction in Rats. Int. J. Mol. Sci. 2022, 23, 10984. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms231810984
Nogueira S, Barbosa J, Faria J, Sá SI, Cardoso A, Soares R, Fonseca BM, Leal S. Unhealthy Diets Induce Distinct and Regional Effects on Intestinal Inflammatory Signalling Pathways and Long-Lasting Metabolic Dysfunction in Rats. International Journal of Molecular Sciences. 2022; 23(18):10984. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms231810984
Chicago/Turabian StyleNogueira, Sofia, Joana Barbosa, Juliana Faria, Susana I. Sá, Armando Cardoso, Raquel Soares, Bruno M. Fonseca, and Sandra Leal. 2022. "Unhealthy Diets Induce Distinct and Regional Effects on Intestinal Inflammatory Signalling Pathways and Long-Lasting Metabolic Dysfunction in Rats" International Journal of Molecular Sciences 23, no. 18: 10984. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms231810984