Automatic Evaluation for Bioengineering of Human Artificial Ovary: A Model for Fertility Preservation for Prepubertal Female Patients with a Malignant Tumor
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Ethics Permission and Informed Consent Statement
4.2. Cryopreservation of Ovarian Tissue and Thawing
4.3. Isolation of Follicles
4.4. Follicles Encapsulation and In Vitro Culture
4.5. Artificial Ovary Imaging
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Bejarano-Quisoboni, D.; Pelletier-Fleury, N.; Allodji, R.S.; Lacour, B.; GrosClaude, P.; Pacquement, H.; Doz, F.; Berchery, D.; Pluchart, C.; Bondiau, P.Y.; et al. Health care expenditures among long-term survivors of pediatric solid tumors: Results from the French Childhood Cancer Survivor Study (FCCSS) and the French network of cancer registries (FRANCIM). PLoS ONE 2022, 17, e0267317. [Google Scholar] [CrossRef] [PubMed]
- Brown, M.C.; Levitt, G.A.; Frey, E.; Bárdi, E.; Haupt, R.; Hjorth, L.; Kremer, L.; Kuehni, C.E.; Lettner, C.; Mulder, R.L.; et al. The views of European clinicians on guidelines for long-term follow-up of childhood cancer survivors. Pediatr. Blood Cancer 2015, 62, 322–328. [Google Scholar] [CrossRef] [PubMed]
- Hawkins, M.M.; Lancashire, E.R.; Winter, D.L.; Frobisher, C.; Reulen, R.C.; Taylor, A.J.; Stevens, M.C.; Jenney, M. The British Childhood Cancer Survivor Study: Objectives, methods, population structure, response rates and initial descriptive information. Pediatr. Blood Cancer 2008, 50, 1018–1025. [Google Scholar] [CrossRef] [PubMed]
- Hoogendijk, R.; van der Lugt, J.; van Vuurden, D.; Kremer, L.; Wesseling, P.; Hoving, E.; Karim-Kos, H.E. Survival rates of children and young adolescents with CNS tumors improved in the Netherlands since 1990: A population-based study. Neurooncol. Adv. 2022, 4, vdab183. [Google Scholar] [CrossRef] [PubMed]
- Meernik, C.; Mersereau, J.E.; Baggett, C.D.; Engel, S.M.; Moy, L.M.; Cannizzaro, N.T.; Peavey, M.; Kushi, L.H.; Chao, C.R.; Nichols, H.B. Fertility Preservation and Financial Hardship among Adolescent and Young Adult Women with Cancer. Cancer Epidemiol. Biomark. Prev. 2022, 31, 1043–1051. [Google Scholar] [CrossRef] [PubMed]
- Rodriguez-Wallberg, K.A.; Milenkovic, M.; Papaikonomou, K.; Keros, V.; Gustafsson, B.; Sergouniotis, F.; Wikander, I.; Perot, R.; Borgström, B.; Ljungman, P.; et al. Successful pregnancies after transplantation of ovarian tissue retrieved and cryopreserved at time of childhood acute lymphoblastic leukemia—A case report. Haematologica 2021, 106, 2783–2787. [Google Scholar] [CrossRef] [PubMed]
- Di Tucci, C.; Galati, G.; Mattei, G.; Chinè, A.; Fracassi, A.; Muzii, L. Fertility after Cancer: Risks and Successes. Cancers 2022, 14, 2500. [Google Scholar] [CrossRef]
- Khattak, H.; Amorim, C.A. What are my options? Fertility preservation methods for young girls and women. Fertil. Steril. 2022, 117, 1277–1278. [Google Scholar] [CrossRef]
- Burnik Papler, T.; Vrtacnik Bokal, E.; Jančar, N. Female reproductive potential after oncological treatment: A rare case report of acute myeloid leukemia in monozygotic twin sisters with literature review. J. Ovarian Res. 2020, 13, 2. [Google Scholar] [CrossRef] [Green Version]
- Nguyen, T.Y.T.; Cacciottola, L.; Camboni, A.; Ravau, J.; De Vos, M.; Demeestere, I.; Donnez, J.; Dolmans, M.M. Ovarian tissue cryopreservation and transplantation in patients with central nervous system tumours. Hum. Reprod. 2021, 36, 1296–1309. [Google Scholar] [CrossRef]
- Anderson, R.A.; Cui, W. Improving analysis of ovarian function and female fertility in cancer survivors. Fertil. Steril. 2022, 117, 1057–1058. [Google Scholar] [CrossRef] [PubMed]
- Mahmood, S.; Drakeley, A.; Homburg, R.; Bambang, K. Fertility Preservation in Female Patients with Cancer. Clin. Oncol. 2022, 34, 508–513. [Google Scholar] [CrossRef] [PubMed]
- Zver, T.; Frontczak, S.; Poirot, C.; Rives-Feraille, A.; Leroy-Martin, B.; Koscinski, I.; Arbez-Gindre, F.; Garnache-Ottou, F.; Roux, C.; Amiot, C. Minimal residual disease detection by multicolor flow cytometry in cryopreserved ovarian tissue from leukemia patients. J. Ovarian Res. 2022, 15, 9. [Google Scholar] [CrossRef] [PubMed]
- Chen, J.; Torres-de la Roche, L.A.; Kahlert, U.D.; Isachenko, V.; Huang, H.; Hennefründ, J.; Yan, X.; Chen, Q.; Shi, W.; Li, Y. Artificial Ovary for Young Female Breast Cancer Patients. Front. Med. 2022, 9, 837022. [Google Scholar] [CrossRef] [PubMed]
- Picton, H.M. Therapeutic Potential of In Vitro-Derived Oocytes for the Restoration and Treatment of Female Fertility. Annu. Rev. Anim. Biosci. 2022, 10, 281–301. [Google Scholar] [CrossRef]
- Xiao, S.; Coppeta, J.R.; Rogers, H.B.; Isenberg, B.C.; Zhu, J.; Olalekan, S.A.; McKinnon, K.E.; Dokic, D.; Rashedi, A.S.; Haisenleder, D.J.; et al. A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. Nat. Commun. 2017, 8, 14584. [Google Scholar] [CrossRef] [Green Version]
- Dadashzadeh, A.; Moghassemi, S.; Shavandi, A.; Amorim, C.A. A review on biomaterials for ovarian tissue engineering. Acta Biomater. 2021, 135, 48–63. [Google Scholar] [CrossRef]
- Mousset-Simeón, N.; Jouannet, P.; Le Cointre, L.; Coussieu, C.; Poirot, C. Comparison of three in vitro culture systems for maturation of early preantral mouse ovarian follicles. Zygote 2005, 13, 167–175. [Google Scholar] [CrossRef]
- Yoshino, T.; Suzuki, T.; Nagamatsu, G.; Yabukami, H.; Ikegaya, M.; Kishima, M.; Kita, H.; Imamura, T.; Nakashima, K.; Nishinakamura, R.; et al. Generation of ovarian follicles from mouse pluripotent stem cells. Science 2021, 373, eabe0237. [Google Scholar] [CrossRef]
- Telfer, E.E. Future developments: In vitro growth (IVG) of human ovarian follicles. Acta Obstet. Gynecol. Scand. 2019, 98, 653–658. [Google Scholar] [CrossRef]
- Xu, M.; West, E.; Shea, L.D.; Woodruff, T.K. Identification of a stage-specific permissive in vitro culture environment for follicle growth and oocyte development. Biol. Reprod. 2006, 75, 916–923. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ouni, E.; Bouzin, C.; Dolmans, M.M.; Marbaix, E.; Pyr dit Ruys, S.; Vertommen, D.; Amorim, C.A. Spatiotemporal changes in mechanical matrisome components of the human ovary from prepuberty to menopause. Hum. Reprod. 2020, 35, 1391–1410. [Google Scholar] [CrossRef] [PubMed]
- Felder, S.; Masasa, H.; Orenbuch, A.; Levaot, N.; Shachar Goldenberg, M.; Cohen, S. Reconstruction of the ovary microenvironment utilizing macroporous scaffold with affinity-bound growth factors. Biomaterials 2019, 205, 11–22. [Google Scholar] [CrossRef] [PubMed]
- Wu, T.; Gao, Y.Y.; Su, J.; Tang, X.N.; Chen, Q.; Ma, L.W.; Zhang, J.J.; Wu, J.M.; Wang, S.X. Three-dimensional bioprinting of artificial ovaries by an extrusion-based method using gelatin-methacryloyl bioink. Climacteric 2022, 25, 170–178. [Google Scholar] [CrossRef]
- Nagyová, E.; Němcová, L.; Camaioni, A. Cumulus Extracellular Matrix Is an Important Part of Oocyte Microenvironment in Ovarian Follicles: Its Remodeling and Proteolytic Degradation. Int. J. Mol. Sci. 2021, 23, 54. [Google Scholar] [CrossRef]
- Chen, J.; Todorov, P.; Isachenko, E.; Rahimi, G.; Mallmann, P.; Isachenko, V. Construction and cryopreservation of an artificial ovary in cancer patients as an element of cancer therapy and a promising approach to fertility restoration. Hum. Fertil. 2021, 1–21. [Google Scholar] [CrossRef]
- Jones, A.S.K.; Shikanov, A. Ovarian tissue cryopreservation and novel bioengineering approaches for fertility preservation. Curr. Breast Cancer Rep. 2020, 12, 351–360. [Google Scholar] [CrossRef]
- Telfer, E.; Torrance, C.; Gosden, R.G. Morphological study of cultured preantral ovarian follicles of mice after transplantation under the kidney capsule. J. Reprod. Fertil. 1990, 89, 565–571. [Google Scholar] [CrossRef] [Green Version]
- Gosden, R.G. Restitution of fertility in sterilized mice by transferring primordial ovarian follicles. Hum. Reprod. 1990, 5, 499–504. [Google Scholar] [CrossRef]
- Dolmans, M.M.; Martinez-Madrid, B.; Gadisseux, E.; Guiot, Y.; Yuan, W.Y.; Torre, A.; Camboni, A.; Van Langendonckt, A.; Donnez, J. Short-term transplantation of isolated human ovarian follicles and cortical tissue into nude mice. Reproduction 2007, 134, 253–262. [Google Scholar] [CrossRef]
- Dolmans, M.M.; Yuan, W.Y.; Camboni, A.; Torre, A.; Van Langendonckt, A.; Martinez-Madrid, B.; Donnez, J. Development of antral follicles after xenografting of isolated small human preantral follicles. Reprod. Biomed. Online 2008, 16, 705–711. [Google Scholar] [CrossRef]
- Reddy, M.S.B.; Ponnamma, D.; Choudhary, R.; Sadasivuni, K.K. A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds. Polymers 2021, 13, 1105. [Google Scholar] [CrossRef] [PubMed]
- Klegerman, M.E.; Moody, M.R.; Huang, S.L.; Peng, T.; Laing, S.T.; Govindarajan, V.; Danila, D.; Tahanan, A.; Rahbar, M.H.; Vela, D.; et al. Demonstration of ultrasound-mediated therapeutic delivery of fibrin-targeted pioglitazone-loaded echogenic liposomes into the arterial bed for attenuation of peri-stent restenosis. J. Drug Target 2022, 9, 1–10. [Google Scholar] [CrossRef] [PubMed]
- Reis, C.H.B.; Buchaim, D.V.; Ortiz, A.C.; Fideles, S.O.M.; Dias, J.A.; Miglino, M.A.; Teixeira, D.B.; Pereira, E.; da Cunha, M.R.; Buchaim, R.L. Application of Fibrin Associated with Photobiomodulation as a Promising Strategy to Improve Regeneration in Tissue Engineering: A Systematic Review. Polymers 2022, 14, 3150. [Google Scholar] [CrossRef] [PubMed]
- Pleguezuelos-Beltrán, P.; Gálvez-Martín, P.; Nieto-García, D.; Marchal, J.A.; López-Ruiz, E. Advances in spray products for skin regeneration. Bioact. Mater. 2022, 16, 187–203. [Google Scholar] [CrossRef] [PubMed]
- Singh, M.; Akkaya, S.; Preuß, M.; Rademacher, F.; Tohidnezhad, M.; Kubo, Y.; Behrendt, P.; Weitkamp, J.T.; Wedel, T.; Lucius, R.; et al. Platelet-Released Growth Factors Influence Wound Healing-Associated Genes in Human Keratinocytes and Ex Vivo Skin Explants. Int. J. Mol. Sci. 2022, 23, 2827. [Google Scholar] [CrossRef]
- Szczech, M.; Maciorowski, R. Microencapsulation Technique with Organic Additives for Biocontrol Agents. J. Hortic. Res. 2016, 24, 111–122. [Google Scholar] [CrossRef] [Green Version]
- Pawar, S.N.; Edgar, K.J. Alginate derivatization: A review of chemistry, properties and applications. Biomaterials 2012, 33, 3279–3305. [Google Scholar] [CrossRef]
- Chiti, M.C.; Dolmans, M.M.; Mortiaux, L.; Zhuge, F.; Ouni, E.; Shahri, P.A.K.; Van Ruymbeke, E.; Champagne, S.D.; Donnez, J.; Amorim, C.A. A novel fibrin-based artificial ovary prototype resembling human ovarian tissue in terms of architecture and rigidity. J. Assist. Reprod. Genet. 2018, 35, 41–48. [Google Scholar] [CrossRef]
- Chiti, M.C.; Dolmans, M.M.; Hobeika, M.; Cernogoraz, A.; Donnez, J.; Amorim, C.A. A modified and tailored human follicle isolation procedure improves follicle recovery and survival. J. Ovarian Res. 2017, 10, 71. [Google Scholar] [CrossRef]
- Chiti, M.C.; Dolmans, M.M.; Lucci, C.M.; Paulini, F.; Donnez, J.; Amorim, C.A. Further insights into the impact of mouse follicle stage on graft outcome in an artificial ovary environment. Mol. Hum. Reprod. 2017, 23, 381–392. [Google Scholar] [CrossRef] [PubMed]
- Chiti, M.C.; Dolmans, M.M.; Orellana, O.; Soares, M.; Paulini, F.; Donnez, J.; Amorim, C.A. Influence of follicle stage on artificial ovary outcome using fibrin as a matrix. Hum. Reprod. 2016, 31, 2898. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Beudert, M.; Gutmann, M.; Lühmann, T.; Meinel, L. Fibrin Sealants: Challenges and Solutions. ACS Biomater. Sci. Eng. 2022, 8, 2220–2231. [Google Scholar] [CrossRef] [PubMed]
- Bodega, F.; Sironi, C.; Zocchi, L.; Porta, C. Optimization of Fibrin Scaffolds to Study Friction in Cultured Mesothelial Cells. Int. J. Mol. Sci. 2022, 23, 4980. [Google Scholar] [CrossRef] [PubMed]
- Mounsif, M.; Smouni, F.E.; Bouziane, A. Fibrin sealant versus sutures in periodontal surgery: A systematic review. Ann. Med. Surg. 2022, 76, 103539. [Google Scholar] [CrossRef] [PubMed]
- Morris, M.P.; Patel, V.; Christopher, A.N.; Broach, R.; Harbison, S.P.; Fischer, J.P. Three-Year Clinical Outcomes and Quality of Life after Retromuscular Resorbable Mesh Repair Using Fibrin Glue. Plast Reconstr. Surg. 2022, 149, 1440–1447. [Google Scholar] [CrossRef]
- Salama, M.; Anazodo, A.; Woodruff, T.K. Preserving fertility in female patients with hematological malignancies: The key points. Expert Rev. Hematol. 2019, 12, 375–377. [Google Scholar] [CrossRef]
- Salama, M.; Anazodo, A.; Woodruff, T.K. Preserving fertility in female patients with hematological malignancies: A multidisciplinary oncofertility approach. Ann. Oncol. 2019, 30, 1760–1775. [Google Scholar] [CrossRef] [Green Version]
- Li, J.T.; Liu, J.J.; Song, Z.W.; Lu, X.L.; Wang, H.X.; Zhang, J.M. Targeting against the activity of the NLRP3 inflammasome is a potential therapy for rat testicular tissue cryopreservation and transplantation. Andrologia 2021, 53, e14223. [Google Scholar] [CrossRef]
- Soares, M.; Saussoy, P.; Sahrari, K.; Amorim, C.A.; Donnez, J.; Dolmans, M.M. Is transplantation of a few leukemic cells inside an artificial ovary able to induce leukemia in an experimental model? J. Assist. Reprod. Genet. 2015, 32, 597–606. [Google Scholar] [CrossRef]
- Soares, M.; Sahrari, K.; Amorim, C.A.; Saussoy, P.; Donnez, J.; Dolmans, M.M. Evaluation of a human ovarian follicle isolation technique to obtain disease-free follicle suspensions before safely grafting to cancer patients. Fertil. Steril. 2015, 104, 672–680.e672. [Google Scholar] [CrossRef] [PubMed]
- Mouloungui, E.; Zver, T.; Roux, C.; Amiot, C. A protocol to isolate and qualify purified human preantral follicles in cases of acute leukemia, for future clinical applications. J. Ovarian Res. 2018, 11, 4. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Isachenko, V.; Todorov, P.; Isachenko, E.; Rahimi, G.; Tchorbanov, A.; Mihaylova, N.; Manoylov, I.; Mallmann, P.; Merzenich, M. Long-Time Cooling before Cryopreservation Decreased Translocation of Phosphatidylserine (Ptd-L-Ser) in Human Ovarian Tissue. PLoS ONE 2015, 10, e0129108. [Google Scholar] [CrossRef] [PubMed]
- Wang, W.; Salama, M.; Todorov, P.; Spitkovsky, D.; Isachenko, E.; Bongaarts, R.; Rahimi, G.; Mallmann, P.; Sukhikh, G.; Isachenko, V. New method of FACS analyzing and sorting of intact whole ovarian fragments (COPAS) after long time (24 h) cooling to 5 °C before cryopreservation. Cell Tissue Bank. 2021, 22, 487–498. [Google Scholar] [CrossRef]
- Yin, H.; Kristensen, S.G.; Jiang, H.; Rasmussen, A.; Andersen, C.Y. Survival and growth of isolated pre-antral follicles from human ovarian medulla tissue during long-term 3D culture. Hum. Reprod. 2016, 31, 1531–1539. [Google Scholar] [CrossRef] [Green Version]
- Gougeon, A. Regulation of ovarian follicular development in primates: Facts and hypotheses. Endocr. Rev. 1996, 17, 121–155. [Google Scholar] [CrossRef]
- Fortune, J.E. The early stages of follicular development: Activation of primordial follicles and growth of preantral follicles. Anim. Reprod. Sci. 2003, 78, 135–163. [Google Scholar] [CrossRef]
Optical Microscopy (n = 5) (Follicles Amounts, Total = 212) 1 | Confocal Microscopy + Imaris Reconstruction (n = 5) (Follicle Spherical Surface Area, μm2) 1 | |
---|---|---|
Day 1 | Primordial = 169 Primary = 26 Secondary = 17 | 2,365,971.01 |
Day 3 | Primordial = 104 Primary = 85 Secondary = 23 | 2,629,148.77 (+11.123%) |
Day 5 | Primordial = 39 Primary = 128 Secondary = 45 | 3,040,046.53 (+15.629%) |
Day 7 | Primordial = 21 Primary = 135 Secondary = 56 | 2,405,424.01 (−20.875%) |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Wang, W.; Pei, C.; Isachenko, E.; Zhou, Y.; Wang, M.; Rahimi, G.; Liu, W.; Mallmann, P.; Isachenko, V. Automatic Evaluation for Bioengineering of Human Artificial Ovary: A Model for Fertility Preservation for Prepubertal Female Patients with a Malignant Tumor. Int. J. Mol. Sci. 2022, 23, 12419. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232012419
Wang W, Pei C, Isachenko E, Zhou Y, Wang M, Rahimi G, Liu W, Mallmann P, Isachenko V. Automatic Evaluation for Bioengineering of Human Artificial Ovary: A Model for Fertility Preservation for Prepubertal Female Patients with a Malignant Tumor. International Journal of Molecular Sciences. 2022; 23(20):12419. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232012419
Chicago/Turabian StyleWang, Wanxue, Cheng Pei, Evgenia Isachenko, Yang Zhou, Mengying Wang, Gohar Rahimi, Wensheng Liu, Peter Mallmann, and Vladimir Isachenko. 2022. "Automatic Evaluation for Bioengineering of Human Artificial Ovary: A Model for Fertility Preservation for Prepubertal Female Patients with a Malignant Tumor" International Journal of Molecular Sciences 23, no. 20: 12419. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232012419